(Re)organisation of the somatosensory system after early brain lesion: A lateralization index fMRI study.
Brain lesion
Cerebral palsy
Functional MRI
Lateralization index
Plasticity
Sensory function
Journal
Annals of physical and rehabilitation medicine
ISSN: 1877-0665
Titre abrégé: Ann Phys Rehabil Med
Pays: Netherlands
ID NLM: 101502773
Informations de publication
Date de publication:
Oct 2020
Oct 2020
Historique:
received:
28
09
2018
revised:
14
01
2019
accepted:
03
02
2019
pubmed:
3
3
2019
medline:
26
11
2021
entrez:
3
3
2019
Statut:
ppublish
Résumé
To evaluate the relationship between neural (re)organization of the somatosensory cortex and impairment of sensory function (2-point discrimination [2PD]) in individuals with unilateral cerebral palsy. We included 21 individuals with unilateral cerebral palsy. 2PD thresholds were evaluated on thumb pads, and activation of the somatosensory cortex was recorded by functional MRI (fMRI) during passive movements of the affected hand. A lateralization index (LI) was calculated for the primary sensory (S1) and secondary sensory (S2) cortices and the correlation between the LI and 2PD thresholds was analysed. We found a significant negative correlation between the 2PD thresholds and the S2 LI (r=-0.5, one-tailed P-value=0.01) and a trend towards a negative correlation with the S1 LI (r=-0.4, one-tailed P-value=0.05). High levels of activation in the contralesional hemisphere were associated with high levels of sensory impairment in individuals with unilateral cerebral palsy. The interhemispheric (re)organization of the somatosensory system may not effectively compensate for somatosensory impairment.
Identifiants
pubmed: 30825646
pii: S1877-0657(19)30031-4
doi: 10.1016/j.rehab.2019.02.001
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
416-421Informations de copyright
Copyright © 2019 Elsevier Masson SAS. All rights reserved.