Candida albicans: An Emerging Yeast Model to Study Eukaryotic Genome Plasticity.
Candida albicans
centromere
genome dynamics
mating
morphogenesis
recombination
replication and repair
yeast
Journal
Trends in genetics : TIG
ISSN: 0168-9525
Titre abrégé: Trends Genet
Pays: England
ID NLM: 8507085
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
21
11
2018
revised:
25
01
2019
accepted:
25
01
2019
pubmed:
4
3
2019
medline:
2
7
2020
entrez:
4
3
2019
Statut:
ppublish
Résumé
Saccharomyces cerevisiae and Schizosaccharomyces pombe have served as uncontested unicellular model organisms, as major discoveries made in the field of genome biology using yeast genetics have proved to be relevant from yeast to humans. The yeast Candida albicans has attracted much attention because of its ability to switch between a harmless commensal and a dreaded human pathogen. C. albicans bears unique features regarding its life cycle, genome structure, and dynamics, and their links to cell biology and adaptation to environmental challenges. Examples include a unique reproduction cycle with haploid, diploid, and tetraploid forms; a distinctive organisation of chromosome hallmarks; a highly dynamic genome, with extensive karyotypic variations, including aneuploidies, isochromosome formation, and loss-of-heterozygosity; and distinctive links between the response to DNA alterations and cell morphology. These features have made C. albicans emerge as a new and attractive unicellular model to study genome biology and dynamics in eukaryotes.
Identifiants
pubmed: 30826131
pii: S0168-9525(19)30015-0
doi: 10.1016/j.tig.2019.01.005
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
292-307Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.