The transcriptional regulation of PER protein in Drosophila.

Animals Circadian Rhythm / genetics Drosophila Proteins / genetics Drosophila melanogaster / genetics Gene Expression Regulation Models, Genetic Period Circadian Proteins / genetics Transcription, Genetic
Circadian rhythm Drosophila Limit cycles per mRNA

Journal

Journal of theoretical biology
ISSN: 1095-8541
Titre abrégé: J Theor Biol
Pays: England
ID NLM: 0376342

Informations de publication

Date de publication:
21 05 2019
Historique:
received: 26 09 2018
revised: 22 02 2019
accepted: 27 02 2019
pubmed: 4 3 2019
medline: 10 7 2020
entrez: 4 3 2019
Statut: ppublish

Résumé

We propose an auto-activation model controlled by a negative feedback transcriptional regulator to describe the circadian rhythm in Drosophila melanogaster. The model is specific to eukaryote organisms and oscillations are induced by a two-compartment approach, the nucleus and the cytoplasm. The communication between compartments is done through diffusive coupling, simulating the protein channels connecting the interior of the nucleus with the cytoplasm. The same model without compartments has no oscillations. We calibrate the model with data from per mRNA concentration.

Identifiants

DOI: 10.1016/j.jtbi.2019.02.022 PMID: 30826337
pubmed: 30826337
pii: S0022-5193(19)30091-8
doi: 10.1016/j.jtbi.2019.02.022
pii:
doi:

Substances chimiques

Drosophila Proteins 0
PER protein, Drosophila 0
Period Circadian Proteins 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

12-17

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

Rui Dilão (R)

Universidade de Lisboa, IST, Dep. of Physics, Nonlinear Dynamics Group, Av. Rovisco Pais, Lisbon 1049-001, Portugal. Electronic address: ruidilao@tecnico.ulisboa.pt.

Bárbara Mota (B)

Universidade de Lisboa, IST, Dep. of Physics, Nonlinear Dynamics Group, Av. Rovisco Pais, Lisbon 1049-001, Portugal. Electronic address: barbara.mota@tecnico.ulisboa.pt.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › The transcriptional regulation of PER protein...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes chronobiologiques › Périodicité › Rythme circadien › The transcriptional regulation of PER protein...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines d'arthropode › Protéines d'insecte › Protéines de Drosophila › The transcriptional regulation of PER protein...
questionsmedicales.fr › Eucaryotes › Animaux › Invertébrés › Arthropodes › Insectes › Pterygota › Neoptera › Holometabola › Diptera › Drosophilidae › Drosophila › Drosophila melanogaster › The transcriptional regulation of PER protein...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › The transcriptional regulation of PER protein...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles génétiques › The transcriptional regulation of PER protein...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs nucléocytoplasmiques › Protéines circadiennes Period › The transcriptional regulation of PER protein...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › The transcriptional regulation of PER protein...