Epigenetic marks of prenatal air pollution exposure found in multiple tissues relevant for child health.

Air Pollutants / analysis Air Pollution / analysis Child Health DNA Methylation Epigenomics Female Humans Infant Health Infant, Newborn Male Maternal Exposure Maternal-Fetal Exchange Nitrogen Dioxide / analysis Ozone / analysis Placenta / chemistry Pregnancy
DNA methylation Epigenetic Genome-scale Placenta Prenatal air pollution exposure Sex differences

Journal

Environment international
ISSN: 1873-6750
Titre abrégé: Environ Int
Pays: Netherlands
ID NLM: 7807270

Informations de publication

Date de publication:
05 2019
Historique:
received: 04 10 2018
revised: 05 01 2019
accepted: 10 02 2019
pubmed: 4 3 2019
medline: 31 10 2019
entrez: 4 3 2019
Statut: ppublish

Résumé

Prenatal air pollution exposure has been linked to many adverse health conditions in the offspring. However, little is known about the mechanisms underlying these associations. Epigenetics may be one plausible biologic link. Here, we sought to identify site-specific and global DNA methylation (DNAm) changes, in developmentally relevant tissues, associated with prenatal exposure to nitrogen dioxide (NO Genome-scale DNAm measurements were obtained using the Infinium HumanMethylation450k platform for 133 placenta and 175 cord blood specimens from Early Autism Risk Longitudinal Investigation (EARLI) neonates. Ambient NO We identified global and locus-specific changes in DNA methylation related to prenatal exposure to NO We observed global, locus, and sex-specific methylation changes associated with prenatal NO

Sections du résumé

BACKGROUND
Prenatal air pollution exposure has been linked to many adverse health conditions in the offspring. However, little is known about the mechanisms underlying these associations. Epigenetics may be one plausible biologic link. Here, we sought to identify site-specific and global DNA methylation (DNAm) changes, in developmentally relevant tissues, associated with prenatal exposure to nitrogen dioxide (NO
METHODS
Genome-scale DNAm measurements were obtained using the Infinium HumanMethylation450k platform for 133 placenta and 175 cord blood specimens from Early Autism Risk Longitudinal Investigation (EARLI) neonates. Ambient NO
RESULTS
We identified global and locus-specific changes in DNA methylation related to prenatal exposure to NO
CONCLUSIONS
We observed global, locus, and sex-specific methylation changes associated with prenatal NO

Identifiants

DOI: 10.1016/j.envint.2019.02.028 PMID: 30826615 PMC: PMC6446941
pubmed: 30826615
pii: S0160-4120(18)32272-4
doi: 10.1016/j.envint.2019.02.028
pmc: PMC6446941
mid: NIHMS1522865
pii:
doi:

Substances chimiques

Air Pollutants 0
Ozone 66H7ZZK23N
Nitrogen Dioxide S7G510RUBH

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

363-376

Subventions

Organisme : NIEHS NIH HHS
ID : R01 ES023780
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES017646
Pays : United States
Organisme : Autism Speaks
ID : AS7785
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES016443
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES025531
Pays : United States

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.

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Auteurs

Christine Ladd-Acosta (C)

Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. Electronic address: claddac1@jhu.edu.

Jason I Feinberg (JI)

Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Shannon C Brown (SC)

Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Frederick W Lurmann (FW)

Sonoma Technology, Inc., Petaluma, CA, USA.

Lisa A Croen (LA)

Autism Research Program, Division of Research, Kaiser Permanente, Oakland, CA, USA.

Irva Hertz-Picciotto (I)

Department of Public Health Sciences, MIND (Medical Investigations of Neurodevelopmental Disorders) Institute, University of California, Davis, CA, USA.

Craig J Newschaffer (CJ)

A.J. Drexel Autism Institute and Department of Epidemiology and Biostatistics, Drexel University School of Public Health, Philadelphia, PA, USA.

Andrew P Feinberg (AP)

Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Center for Epigenetics, Johns Hopkins University School of Medicine, Baltimore, MD, USA; Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

M Daniele Fallin (MD)

Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

Heather E Volk (HE)

Wendy Klag Center for Autism and Developmental Disabilities, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Mental Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA; Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions toxiques › Polluants environnementaux › Polluants atmosphériques › Epigenetic marks of prenatal air pollution...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Pollution de l'air › Epigenetic marks of prenatal air pollution...
questionsmedicales.fr › Caractéristiques de la population › Santé › Santé de l'enfant › Epigenetic marks of prenatal air pollution...
questionsmedicales.fr › Phénomènes génétiques › Méthylation de l'ADN › Epigenetic marks of prenatal air pollution...
questionsmedicales.fr › Disciplines des sciences naturelles › Disciplines des sciences biologiques › Biologie › Génétique › Génomique › Épigénomique › Epigenetic marks of prenatal air pollution...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Epigenetic marks of prenatal air pollution...
questionsmedicales.fr › Caractéristiques de la population › Santé › Santé infantile › Epigenetic marks of prenatal air pollution...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Epigenetic marks of prenatal air pollution...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Pollution de l'environnement › Exposition environnementale › Exposition maternelle › Epigenetic marks of prenatal air pollution...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Échange foetomaternel › Epigenetic marks of prenatal air pollution...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Oxydes › Oxydes d'azote › Dioxyde d'azote › Epigenetic marks of prenatal air pollution...
questionsmedicales.fr › Produits chimiques inorganiques › Gaz › Oxygène › Ozone › Epigenetic marks of prenatal air pollution...
questionsmedicales.fr › Structures de l'embryon › Placenta › Epigenetic marks of prenatal air pollution...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Epigenetic marks of prenatal air pollution...