Reduced CXCL1/GRO chemokine plasma levels are a possible biomarker of elderly depression.
Biomarkers
Chemokines
Cytokine weighted score
Cytokines
Inflammation
Major depression
Journal
Journal of affective disorders
ISSN: 1573-2517
Titre abrégé: J Affect Disord
Pays: Netherlands
ID NLM: 7906073
Informations de publication
Date de publication:
15 Apr 2019
15 Apr 2019
Historique:
received:
08
11
2018
revised:
11
02
2019
accepted:
12
02
2019
pubmed:
4
3
2019
medline:
14
6
2019
entrez:
4
3
2019
Statut:
ppublish
Résumé
Depression is the single largest contributor to non-fatal health loss worldwide. A role of inflammation in major depressive disorder (MDD) was suggested, and we sought to determine if cytokine levels predict the severity of depressive symptomatology or distinguish MDD patients from healthy controls (HCs). The severity of depressive symptoms and cognitive impairment were assessed by the Korean version of the Geriatric Depression Scale (GDS-K) and Mini-Mental State Examination (MMSE-KC) in 152 elderly subjects (76 with MDD). Plasma levels of 28 cytokines were measured and analysed as continuous predictors or dichotomized using the median value. The association between individual cytokines, MDD risk and depressive symptoms severity was investigated using multiple logistic and linear regressions that included the relevant covariates. A Cytokine Weighted Score (CWS) was calculated by weighting cytokines according to previously reported effect sizes on MDD risk. Sensitivity analyses were performed excluding subjects with significant cognitive impairment. CXCL10/IP-10 levels were higher in subjects with MDD vs. HCs while the opposite was observed for CXCL1/GRO. Only the second association survived after adjusting for possible confounders and excluding subjects with severe cognitive impairment. Using dichotomized cytokine levels, CXCL1/GRO and TNF-α were negatively associated with MDD. The CWS was also negatively associated with MDD. Cytokine levels did not predict the severity of depressive symptoms. Our cross-sectional approach was not able to longitudinally evaluate any temporal fluctuations in the considered cytokine levels. This study found significantly lower CXCL1/GRO chemokine plasma levels in elderly subjects with MDD compared to HCs.
Sections du résumé
BACKGROUND
BACKGROUND
Depression is the single largest contributor to non-fatal health loss worldwide. A role of inflammation in major depressive disorder (MDD) was suggested, and we sought to determine if cytokine levels predict the severity of depressive symptomatology or distinguish MDD patients from healthy controls (HCs).
METHODS
METHODS
The severity of depressive symptoms and cognitive impairment were assessed by the Korean version of the Geriatric Depression Scale (GDS-K) and Mini-Mental State Examination (MMSE-KC) in 152 elderly subjects (76 with MDD). Plasma levels of 28 cytokines were measured and analysed as continuous predictors or dichotomized using the median value. The association between individual cytokines, MDD risk and depressive symptoms severity was investigated using multiple logistic and linear regressions that included the relevant covariates. A Cytokine Weighted Score (CWS) was calculated by weighting cytokines according to previously reported effect sizes on MDD risk. Sensitivity analyses were performed excluding subjects with significant cognitive impairment.
RESULTS
RESULTS
CXCL10/IP-10 levels were higher in subjects with MDD vs. HCs while the opposite was observed for CXCL1/GRO. Only the second association survived after adjusting for possible confounders and excluding subjects with severe cognitive impairment. Using dichotomized cytokine levels, CXCL1/GRO and TNF-α were negatively associated with MDD. The CWS was also negatively associated with MDD. Cytokine levels did not predict the severity of depressive symptoms.
LIMITATIONS
CONCLUSIONS
Our cross-sectional approach was not able to longitudinally evaluate any temporal fluctuations in the considered cytokine levels.
CONCLUSIONS
CONCLUSIONS
This study found significantly lower CXCL1/GRO chemokine plasma levels in elderly subjects with MDD compared to HCs.
Identifiants
pubmed: 30826620
pii: S0165-0327(18)32856-8
doi: 10.1016/j.jad.2019.02.042
pii:
doi:
Substances chimiques
Biomarkers
0
CXCL1 protein, human
0
Chemokine CXCL1
0
Cytokines
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
410-417Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.