Alkene lactones from Persea fulva (Lauraceae): Evaluation of their effects on tumor cell growth in vitro and molecular docking studies.
Animals
Antineoplastic Agents, Phytogenic
/ chemistry
Cell Proliferation
/ drug effects
Cell Survival
/ drug effects
Dose-Response Relationship, Drug
Drug Screening Assays, Antitumor
Lactones
/ chemistry
Lauraceae
/ chemistry
Molecular Docking Simulation
Molecular Structure
Plant Leaves
/ chemistry
Rats
Structure-Activity Relationship
Tumor Cells, Cultured
Alkene lactones
Lauraceae
Molecular docking
Persea fulva
Journal
Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
22
09
2018
revised:
14
01
2019
accepted:
09
02
2019
pubmed:
4
3
2019
medline:
14
4
2020
entrez:
4
3
2019
Statut:
ppublish
Résumé
The new alkene lactone, (3E)-5,6-dihydro-5-(hydroxymethyl)-3-docdecylidenefuran-3(4H)-one (1), named majoranolide B, and three alkene lactones known as majorenolide (2), majoranolide (3) and majorynolide (4) were obtained from the aerial parts of Persea fulva (Lauraceae). The structures were elucidated in light of extensive spectroscopic analysis, including 1D, 2D NMR (
Identifiants
pubmed: 30826627
pii: S0045-2068(18)31060-5
doi: 10.1016/j.bioorg.2019.02.023
pii:
doi:
Substances chimiques
Antineoplastic Agents, Phytogenic
0
Lactones
0
majorynolide
126622-45-5
majorenolide
126622-46-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
665-673Informations de copyright
Copyright © 2019. Published by Elsevier Inc.