The role of the mobile proton in fucose migration.
Carbohydrates
Fucose migration
Infrared spectroscopy
Internal residue loss
Mass spectrometry
Journal
Analytical and bioanalytical chemistry
ISSN: 1618-2650
Titre abrégé: Anal Bioanal Chem
Pays: Germany
ID NLM: 101134327
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
16
11
2018
accepted:
30
01
2019
revised:
11
01
2019
pubmed:
4
3
2019
medline:
31
7
2019
entrez:
4
3
2019
Statut:
ppublish
Résumé
Fucose migration reactions represent a substantial challenge in the analysis of fucosylated glycan structures by mass spectrometry. In addition to the well-established observation of transposed fucose residues in glycan-dissociation product ions, recent experiments show that the rearrangement can also occur in intact glycan ions. These results suggest a low-energy barrier for migration of the fucose residue and broaden the relevance of fucose migration to include other types of mass spectrometry experiments, including ion mobility-mass spectrometry and ion spectroscopy. In this work, we utilize cold-ion infrared spectroscopy to provide further insight into glycan scrambling in intact glycan ions. Our results show that the mobility of the proton is a prerequisite for the migration reaction. For the prototypical fucosylated glycans Lewis x and blood group antigen H-2, the formation of adduct ions or the addition of functional groups with variable proton affinity yields significant differences in the infrared spectra. These changes correlate well with the promotion or inhibition of fucose migration through the presence or absence of a mobile proton.
Identifiants
pubmed: 30826852
doi: 10.1007/s00216-019-01657-w
pii: 10.1007/s00216-019-01657-w
pmc: PMC6611747
doi:
Substances chimiques
Ammonium Compounds
0
Fluorescent Dyes
0
Protons
0
Fucose
28RYY2IV3F
FUT4 protein, human
EC 2.4.1.-
Fucosyltransferases
EC 2.4.1.-
Types de publication
Journal Article
Langues
eng
Pagination
4637-4645Références
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