Positive and Negative Effects of Antipsychotic Medication: An International Online Survey of 832 Recipients.
Antipsychotic drugs
TAE
maudsley side effects
psychosis
second generation
sedation
suicidality.
Journal
Current drug safety
ISSN: 2212-3911
Titre abrégé: Curr Drug Saf
Pays: United Arab Emirates
ID NLM: 101270895
Informations de publication
Date de publication:
2019
2019
Historique:
received:
07
12
2018
revised:
16
02
2019
accepted:
22
02
2019
pubmed:
5
3
2019
medline:
13
2
2020
entrez:
5
3
2019
Statut:
ppublish
Résumé
Antipsychotic medication is currently the treatment of choice for psychosis, but few studies directly survey the first-hand experience of recipients. To ascertain the experiences and opinions of an international sample of users of antipsychotic drugs, regarding positive and negative effects. An online direct-to-consumer questionnaire was completed by 832 users of antipsychotics, from 30 countries - predominantly USA, UK and Australia. This is the largest such sample to date. Over half (56%) thought, the drugs reduced the problems they were prescribed for, but 27% thought they made them worse. Slightly less people found the drugs generally 'helpful' (41%) than found them 'unhelpful' (43%). While 35% reported that their 'quality of life' was 'improved', 54% reported that it was made 'worse'. The average number of adverse effects reported was 11, with an average of five at the 'severe' level. Fourteen effects were reported by 57% or more participants, most commonly: 'Drowsiness, feeling tired, sedation' (92%), 'Loss of motivation' (86%), 'Slowed thoughts' (86%), and 'Emotional numbing' (85%). Suicidality was reported to be a side effect by 58%. Older people reported particularly poor outcomes and high levels of adverse effects. Duration of treatment was unrelated to positive outcomes but significantly related to negative outcomes. Most respondents (70%) had tried to stop taking the drugs. The most common reasons people wanted to stop were the side effects (64%) and worries about long-term physical health (52%). Most (70%) did not recall being told anything at all about side effects. Clinical implications are discussed, with a particular focus on the principles of informed consent, and involving patients in decision making about their own lives.
Sections du résumé
BACKGROUND
BACKGROUND
Antipsychotic medication is currently the treatment of choice for psychosis, but few studies directly survey the first-hand experience of recipients.
OBJECTIVE
OBJECTIVE
To ascertain the experiences and opinions of an international sample of users of antipsychotic drugs, regarding positive and negative effects.
METHODS
METHODS
An online direct-to-consumer questionnaire was completed by 832 users of antipsychotics, from 30 countries - predominantly USA, UK and Australia. This is the largest such sample to date.
RESULTS
RESULTS
Over half (56%) thought, the drugs reduced the problems they were prescribed for, but 27% thought they made them worse. Slightly less people found the drugs generally 'helpful' (41%) than found them 'unhelpful' (43%). While 35% reported that their 'quality of life' was 'improved', 54% reported that it was made 'worse'. The average number of adverse effects reported was 11, with an average of five at the 'severe' level. Fourteen effects were reported by 57% or more participants, most commonly: 'Drowsiness, feeling tired, sedation' (92%), 'Loss of motivation' (86%), 'Slowed thoughts' (86%), and 'Emotional numbing' (85%). Suicidality was reported to be a side effect by 58%. Older people reported particularly poor outcomes and high levels of adverse effects. Duration of treatment was unrelated to positive outcomes but significantly related to negative outcomes. Most respondents (70%) had tried to stop taking the drugs. The most common reasons people wanted to stop were the side effects (64%) and worries about long-term physical health (52%). Most (70%) did not recall being told anything at all about side effects.
CONCLUSION
CONCLUSIONS
Clinical implications are discussed, with a particular focus on the principles of informed consent, and involving patients in decision making about their own lives.
Identifiants
pubmed: 30827259
pii: CDS-EPUB-97007
doi: 10.2174/1574886314666190301152734
pmc: PMC6864560
doi:
Substances chimiques
Antipsychotic Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
173-181Informations de copyright
Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
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