Vitamin D and disease severity in bronchiectasis.

Aged Biomarkers / blood Bronchiectasis / diagnostic imaging Disease Progression Female Humans Inflammation / metabolism Male Middle Aged Prevalence Respiratory Function Tests / methods Retrospective Studies Severity of Illness Index Tomography, X-Ray Computed / methods Vitamin D / blood Vitamin D Deficiency / complications
Biomarker Bronchiectasis Exacerbation Severity Vitamin D

Journal

Respiratory medicine
ISSN: 1532-3064
Titre abrégé: Respir Med
Pays: England
ID NLM: 8908438

Informations de publication

Date de publication:
03 2019
Historique:
received: 14 08 2018
revised: 08 01 2019
accepted: 20 01 2019
entrez: 5 3 2019
pubmed: 5 3 2019
medline: 24 3 2020
Statut: ppublish

Résumé

Bronchiectasis is a complex respiratory disease characterised by permanent dilatation of bronchi. Vitamin D plays a role in infective disease by modulating the inflammation. Patients affected by bronchiectasis are frequently Vitamin D deficient and it correlates with lung function decline. We want to understand if there is a correlation between Vitamin D and clinical and radiological severity of bronchiectasis. We included 57 patients (17 males/40 female with mean age 60 ± 12 years) between October 2017 and March 2018. We excluded patients with cystic fibrosis, traction bronchiectasis and reporting Vitamin D supplementation. Bronchiectasis severity index (BSI) and Bhalla score were calculated, blood inflammatory markers and Vit. D were measured and lung function tests were performed. Vitamin D is deficient in 64% of patients, sufficient in 36% and normal in 7%. Mean BSI is 7.5 ± 5 and mean Bhalla score is 16 ± 4. Vitamin D levels correlate with Bhalla score (R We consider Vitamin D as a good predictor of clinical and radiological severity of bronchiectasis.

Sections du résumé

BACKGROUND
Bronchiectasis is a complex respiratory disease characterised by permanent dilatation of bronchi. Vitamin D plays a role in infective disease by modulating the inflammation. Patients affected by bronchiectasis are frequently Vitamin D deficient and it correlates with lung function decline. We want to understand if there is a correlation between Vitamin D and clinical and radiological severity of bronchiectasis.
METHODS
We included 57 patients (17 males/40 female with mean age 60 ± 12 years) between October 2017 and March 2018. We excluded patients with cystic fibrosis, traction bronchiectasis and reporting Vitamin D supplementation. Bronchiectasis severity index (BSI) and Bhalla score were calculated, blood inflammatory markers and Vit. D were measured and lung function tests were performed.
RESULTS
Vitamin D is deficient in 64% of patients, sufficient in 36% and normal in 7%. Mean BSI is 7.5 ± 5 and mean Bhalla score is 16 ± 4. Vitamin D levels correlate with Bhalla score (R
CONCLUSIONS
We consider Vitamin D as a good predictor of clinical and radiological severity of bronchiectasis.

Identifiants

DOI: 10.1016/j.rmed.2019.01.009 PMID: 30827468
pubmed: 30827468
pii: S0954-6111(19)30018-6
doi: 10.1016/j.rmed.2019.01.009
pii:
doi:

Substances chimiques

Biomarkers 0
Vitamin D 1406-16-2

Types de publication

Journal Article Observational Study

Langues

eng

Sous-ensembles de citation

IM

Pagination

1-5

Informations de copyright

Copyright © 2019 Elsevier Ltd. All rights reserved.

Auteurs

S Ferri (S)

Respiratory Medicine, AOU "Policlinico - Vittorio Emanuele", University of Catania, Catania, Italy.

C Crimi (C)

Respiratory Medicine, AOU "Policlinico - Vittorio Emanuele", University of Catania, Catania, Italy.

E Heffler (E)

Personalized Medicine, Asthma and Allergy, Humanitas Clinical and Research Center, IRCCS, Rozzano, MI, Italy; Department of Biomedical Sciences, Humanitas University, Pieve Emanuele, MI, Italy. Electronic address: enrico.heffler@hunimed.eu.

R Campisi (R)

Respiratory Medicine, AOU "Policlinico - Vittorio Emanuele", University of Catania, Catania, Italy.

A Noto (A)

Department of Anesthesia and Critical Care, AOU Policlinico "G. Martino", University of Messina, Messina, Italy.

N Crimi (N)

Respiratory Medicine, AOU "Policlinico - Vittorio Emanuele", University of Catania, Catania, Italy.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Vitamin D and disease severity in bronchiectasis.
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › Vitamin D and disease severity in bronchiectasis.
questionsmedicales.fr › Maladies de l'appareil respiratoire › Maladies des bronches › Dilatation des bronches › Vitamin D and disease severity in bronchiectasis.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › Vitamin D and disease severity in bronchiectasis.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Vitamin D and disease severity in bronchiectasis.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Vitamin D and disease severity in bronchiectasis.
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Vitamin D and disease severity in bronchiectasis.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Registre civil › Morbidité › Prévalence › Vitamin D and disease severity in bronchiectasis.
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic respiratoire › Tests de la fonction respiratoire › Vitamin D and disease severity in bronchiectasis.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études rétrospectives › Vitamin D and disease severity in bronchiectasis.
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Enquêtes de santé › Indicateurs d'état de santé › Acuité des besoins du patient › Indice de gravité de la maladie › Vitamin D and disease severity in bronchiectasis.
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Tomographie à rayons X › Tomodensitométrie › Vitamin D and disease severity in bronchiectasis.
questionsmedicales.fr › Composés polycycliques › Composés à cycles fusionnés › Stéroïdes › Sécostéroïdes › Vitamine D › Vitamin D and disease severity in bronchiectasis.
questionsmedicales.fr › Maladies métaboliques et nutritionnelles › Troubles nutritionnels › Malnutrition › Maladies de carence › Avitaminoses › Carence en vitamine D › Vitamin D and disease severity in bronchiectasis.