Brain arterial dilatation and the risk of Alzheimer's disease.

Aged Alzheimer Disease / blood Brain / blood supply Carotid Arteries / diagnostic imaging Cerebral Arteries / diagnostic imaging Dilatation, Pathologic / diagnostic imaging Female Humans Longitudinal Studies Magnetic Resonance Imaging Male Risk Factors
Alzheimer's disease Brain arterial diameters Brain arterial dilatation Carotid artery Dementia Dolichoectasia

Journal

Alzheimer's & dementia : the journal of the Alzheimer's Association
ISSN: 1552-5279
Titre abrégé: Alzheimers Dement
Pays: United States
ID NLM: 101231978

Informations de publication

Date de publication:
05 2019
Historique:
received: 17 03 2018
revised: 11 12 2018
accepted: 29 12 2018
pubmed: 5 3 2019
medline: 27 5 2020
entrez: 5 3 2019
Statut: ppublish

Résumé

We tested the hypothesis that brain arterial dilatation increases the risk of Alzheimer's dementia (AD). We studied dementia-free participants in the Washington Heights-Inwood Columbia Aging Project who had a brain MRI and post-MRI dementia adjudication. We measured the axial T2-proton density diameters of the intracranial carotids and basilar diameters and used Cox models to obtain AD hazard ratios and 95% intervals. Of 953 participants (mean age 77 ± 7 y, women 64%, 71% nonwhite) followed on average for 3 ± 3 years, 76 (8%) developed AD. In a model adjusted for demographics, vascular risks, apolipoprotein E (APOE)-ε4, and white matter hyperintensities, larger carotid diameters increased the risk of AD, defined categorically as ≥ 90th percentile (HR 4.34, 1.70-11.11) or continuously (HR 1.44 per SD, 1.07-1.94). Understanding the pathophysiology of the association between AD and brain arterial dilatation may reveal new clues to the vascular contributions to AD.

Identifiants

DOI: 10.1016/j.jalz.2018.12.018 PMID: 30827874 PMC: PMC6511479
pubmed: 30827874
pii: S1552-5260(19)30012-3
doi: 10.1016/j.jalz.2018.12.018
pmc: PMC6511479
mid: NIHMS1519406
pii:
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

666-674

Subventions

Organisme : NIA NIH HHS
ID : P01 AG007232
Pays : United States
Organisme : NIA NIH HHS
ID : RF1 AG054023
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG057709
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG037212
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR001873
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG066162
Pays : United States

Informations de copyright

Copyright © 2019 the Alzheimer's Association. Published by Elsevier Inc. All rights reserved.

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Auteurs

Jose Gutierrez (J)

Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA. Electronic address: jg3233@cumc.columbia.edu.

Vanessa Guzman (V)

Taub Institute for Research on Alzheimer's disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Farid Khasiyev (F)

Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Jennifer Manly (J)

Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Nicole Schupf (N)

Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Howard Andrews (H)

Taub Institute for Research on Alzheimer's disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY, USA.

Richard Mayeux (R)

Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

Adam M Brickman (AM)

Department of Neurology, College of Physicians and Surgeons, Columbia University, New York, NY, USA; Taub Institute for Research on Alzheimer's disease and the Aging Brain, College of Physicians and Surgeons, Columbia University, New York, NY, USA; The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Brain arterial dilatation and the risk of...
questionsmedicales.fr › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Brain arterial dilatation and the risk of...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Brain arterial dilatation and the risk of...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Artères carotides › Brain arterial dilatation and the risk of...
questionsmedicales.fr › Système cardiovasculaire › Vaisseaux sanguins › Artères › Artères cérébrales › Brain arterial dilatation and the risk of...
questionsmedicales.fr › États, signes et symptômes pathologiques › États anatomopathologiques › Dilatation pathologique › Brain arterial dilatation and the risk of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Brain arterial dilatation and the risk of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études longitudinales › Brain arterial dilatation and the risk of...
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Imagerie diagnostique › Tomographie › Imagerie par résonance magnétique › Brain arterial dilatation and the risk of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Brain arterial dilatation and the risk of...