Spatial structure facilitates the accumulation and persistence of antibiotic-resistant mutants in biofilms.
adaptation
antibiotic resistance
bacteria
biofilm
selection
Journal
Evolutionary applications
ISSN: 1752-4571
Titre abrégé: Evol Appl
Pays: England
ID NLM: 101461828
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
02
07
2018
revised:
16
09
2018
accepted:
02
10
2018
entrez:
5
3
2019
pubmed:
5
3
2019
medline:
5
3
2019
Statut:
epublish
Résumé
The emergence and spread of antibiotic resistance in bacterial pathogens are a global crisis. Because many bacterial infections are caused by pathogens that reside in biofilms, we sought to investigate how biofilms influence the evolution of antibiotic resistance. We hypothesize that the inherent spatial structure of biofilms facilitates the accumulation and persistence of spontaneously evolved antibiotic-resistant mutants. To test this, we tracked the frequency of mutants resistant to kanamycin and rifampicin in biofilm populations of
Identifiants
pubmed: 30828370
doi: 10.1111/eva.12728
pii: EVA12728
pmc: PMC6383844
doi:
Types de publication
Journal Article
Langues
eng
Pagination
498-507Références
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