Shedding light on gene therapy: Carbon dots for the minimally invasive image-guided delivery of plasmids and noncoding RNAs - A review.
Bioimaging
Cationic carbon dots
Fluorescent
Gene delivery
Surface passivation
Theranostics
Journal
Journal of advanced research
ISSN: 2090-1232
Titre abrégé: J Adv Res
Pays: Egypt
ID NLM: 101546952
Informations de publication
Date de publication:
Jul 2019
Jul 2019
Historique:
received:
20
11
2018
revised:
10
01
2019
accepted:
10
01
2019
entrez:
5
3
2019
pubmed:
5
3
2019
medline:
5
3
2019
Statut:
epublish
Résumé
Recently, carbon dots (CDs) have attracted great attention due to their superior properties, such as biocompatibility, fluorescence, high quantum yield, and uniform distribution. These characteristics make CDs interesting for bioimaging, therapeutic delivery, optogenetics, and theranostics. Photoluminescence (PL) properties enable CDs to act as imaging-trackable gene nanocarriers, while cationic CDs with high transfection efficiency have been applied for plasmid DNA and siRNA delivery. In this review, we have highlighted the precursors, structure and properties of positively charged CDs to demonstrate the various applications of these materials for nucleic acid delivery. Additionally, the potential of CDs as trackable gene delivery systems has been discussed. Although there are several reports on cellular and animal approaches to investigating the potential clinical applications of these nanomaterials, further systematic multidisciplinary approaches are required to examine the pharmacokinetic and biodistribution patterns of CDs for potential clinical applications.
Identifiants
pubmed: 30828478
doi: 10.1016/j.jare.2019.01.004
pii: S2090-1232(19)30004-9
pmc: PMC6383136
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
81-93Références
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