Benign proliferative epithelial lesions of oral mucosa are infrequently associated with α-, β-, or γ human papillomaviruses.
HPV
Oral
benign
p16
papilloma
Journal
Laryngoscope investigative otolaryngology
ISSN: 2378-8038
Titre abrégé: Laryngoscope Investig Otolaryngol
Pays: United States
ID NLM: 101684963
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
29
03
2018
revised:
20
09
2018
accepted:
03
10
2018
entrez:
5
3
2019
pubmed:
5
3
2019
medline:
5
3
2019
Statut:
epublish
Résumé
Oral papillomas and verruca vulgaris have been associated with human papillomavirus (HPV) infection. However, approximately half of these have remained HPV-negative when tested for mucosal HPV genotypes. In this study, we evaluated presence of α-, β-, and γ-HPVs in benign papillary and verrucous lesions. Eighty-three clinical lesions with suspected HPV etiology were analyzed for HPV types of genus α (n = 24), β (n = 46), and γ (n = 52). Immunohistochemistry was used for p16 as a possible surrogate marker of high-risk HPV, accompanied by Ki-67 proliferation marker. Altogether, α-HPVs were detected in 6.4%, β-HPVs in 2.4%, and γ-HPV in 4.8%. The following genotypes were identified: HPV6, 8, 11, 16, 22, 161, and 170. Neither Ki-67 nor p16 positivity alone were associated with HPV but combined staining showed significant inverse association ( HPV infection is found only in a minority of benign verrucous and papillary oral lesions, with the predominance of α-HPVs. 4.
Sections du résumé
BACKGROUND
BACKGROUND
Oral papillomas and verruca vulgaris have been associated with human papillomavirus (HPV) infection. However, approximately half of these have remained HPV-negative when tested for mucosal HPV genotypes. In this study, we evaluated presence of α-, β-, and γ-HPVs in benign papillary and verrucous lesions.
METHODS
METHODS
Eighty-three clinical lesions with suspected HPV etiology were analyzed for HPV types of genus α (n = 24), β (n = 46), and γ (n = 52). Immunohistochemistry was used for p16 as a possible surrogate marker of high-risk HPV, accompanied by Ki-67 proliferation marker.
RESULTS
RESULTS
Altogether, α-HPVs were detected in 6.4%, β-HPVs in 2.4%, and γ-HPV in 4.8%. The following genotypes were identified: HPV6, 8, 11, 16, 22, 161, and 170. Neither Ki-67 nor p16 positivity alone were associated with HPV but combined staining showed significant inverse association (
CONCLUSION
CONCLUSIONS
HPV infection is found only in a minority of benign verrucous and papillary oral lesions, with the predominance of α-HPVs.
LEVEL OF EVIDENCE
METHODS
4.
Identifiants
pubmed: 30828618
doi: 10.1002/lio2.222
pii: LIO2222
pmc: PMC6383307
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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