Molecular perturbations in cholangiocarcinoma: Is it time for precision medicine?
cholangiocarcinoma
metastasis
precision therapy
Journal
Liver international : official journal of the International Association for the Study of the Liver
ISSN: 1478-3231
Titre abrégé: Liver Int
Pays: United States
ID NLM: 101160857
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
14
01
2019
revised:
26
02
2019
accepted:
26
02
2019
pubmed:
5
3
2019
medline:
16
1
2020
entrez:
5
3
2019
Statut:
ppublish
Résumé
The complexity of cholangiocarcinoma (CCA) cellularity and the molecular perturbation mechanisms that underlie the diversity of growth patterns of this malignancy remain a clinical concern. Tumours of the biliary system display significant intrinsic chemoresistance, caused by significant stromal involvement and genome-wide tumour heterogeneity, hampering disease remission and palliation as well as promoting the metastatic behaviour. It is crucial to advance our present understanding of the risk and molecular pathogenesis of CCA. This will facilitate the delineation of patient subsets based on molecular perturbations and adjust for precision therapies.
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
32-42Subventions
Organisme : Pancreatic Cancer UK
ID : RIF2014_01_BRACONI
Pays : United Kingdom
Informations de copyright
© 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.