Neurocognitive Functioning in Unoperated Adults with Chiari Malformation Type I.
Cerebellar cognitive affective syndrome
Chiari
Cognition
Depression
Neuropsychology
Journal
World neurosurgery
ISSN: 1878-8769
Titre abrégé: World Neurosurg
Pays: United States
ID NLM: 101528275
Informations de publication
Date de publication:
Jun 2019
Jun 2019
Historique:
received:
02
11
2018
revised:
17
02
2019
accepted:
18
02
2019
pubmed:
5
3
2019
medline:
10
1
2020
entrez:
5
3
2019
Statut:
ppublish
Résumé
Adults with Chiari malformation type 1 (CM1) often report cognitive impairment. This cross-sectional study investigates the cognitive and emotional functioning of a sample of adults with CM1 who presented for neurosurgical evaluation prior to intervention. A total of 36 participants (18 patients with CM1 and 18 healthy control subjects) completed a comprehensive neurocognitive battery of tests. Demographic variables (sex, age, handedness, and education) were not statistically significant between the groups. Measures of gross cognition (Mini-Mental State Examination and Repeatable Battery for the Assessment of Neuropsychological Status) were statistically significant between the groups. On a more focused assessment of neurocognitive abilities, the CM1 group performed significantly worse on measures of learning, memory, fluency, and figural copy. A high rate of clinical depression was seen in the CM1 group; however, this did not correlate with cognitive performance. The CM1 group displayed subtle learning, semantic fluency, and complex construction difficulties compared with healthy control subjects. Although not correlated with cognition, adults with CM1 are at high risk for clinical depression.
Identifiants
pubmed: 30831298
pii: S1878-8750(19)30516-9
doi: 10.1016/j.wneu.2019.02.105
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e641-e645Informations de copyright
Copyright © 2019. Published by Elsevier Inc.