PET imaging of freely moving interacting rats.

Animals Brain / physiology Motion Neuroimaging / instrumentation Positron-Emission Tomography / instrumentation Rats Wakefulness
Molecular imaging Motion correction Neurology

Journal

NeuroImage
ISSN: 1095-9572
Titre abrégé: Neuroimage
Pays: United States
ID NLM: 9215515

Informations de publication

Date de publication:
01 05 2019
Historique:
received: 11 12 2018
revised: 06 02 2019
accepted: 25 02 2019
pubmed: 5 3 2019
medline: 21 12 2019
entrez: 5 3 2019
Statut: ppublish

Résumé

Awake rat brain positron emission tomography (PET) has previously been developed to avoid the influence of anesthesia on the rat brain response. In the present work, we further the awake rat brain scanning methodology to establish simultaneous scanning of two interacting rats in a high resolution, large field of view PET scanner. Awake rat imaging methodology based on point source tracking was adapted to be used in a dedicated human brain scanner, the ECAT high resolution research tomograph (HRRT). Rats could freely run on a horizontal platform of 19.4 × 23 cm placed inside the HRRT. The developed methodology was validated using a motion resolution phantom experiment, 3 awake single rat [

Identifiants

DOI: 10.1016/j.neuroimage.2019.02.064 PMID: 30831313
pubmed: 30831313
pii: S1053-8119(19)30160-0
doi: 10.1016/j.neuroimage.2019.02.064
pii:
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

560-567

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Alan Miranda (A)

Molecular Imaging Center Antwerp, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.

Min Su Kang (MS)

Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Mental Health University Institute, 6875 Boulevard LaSalle, Montreal, QC, H4H 1R3, Canada; Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A2B4, Canada.

Stephan Blinder (S)

Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A2B4, Canada.

Reda Bouhachi (R)

Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A2B4, Canada.

Jean-Paul Soucy (JP)

Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A2B4, Canada.

Arturo Aliaga-Aliaga (A)

Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Mental Health University Institute, 6875 Boulevard LaSalle, Montreal, QC, H4H 1R3, Canada; Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A2B4, Canada.

Gassan Massarweh (G)

Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A2B4, Canada.

Sigrid Stroobants (S)

Molecular Imaging Center Antwerp, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium; University Hospital Antwerp, Wilrijkstraat 10, 2650, Antwerp, Belgium.

Steven Staelens (S)

Molecular Imaging Center Antwerp, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium.

Pedro Rosa-Neto (P)

Translational Neuroimaging Laboratory, McGill University Research Centre for Studies in Aging, Douglas Mental Health University Institute, 6875 Boulevard LaSalle, Montreal, QC, H4H 1R3, Canada; Montreal Neurological Institute, McGill University, 3801 University Street, Montreal, QC, H3A2B4, Canada.

Jeroen Verhaeghe (J)

Molecular Imaging Center Antwerp, University of Antwerp, Universiteitsplein 1, 2610, Antwerp, Belgium. Electronic address: jeroen.verhaeghe@uantwerpen.be.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › PET imaging of freely moving interacting rats.
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › PET imaging of freely moving interacting rats.
questionsmedicales.fr › Phénomènes physiques › Déplacement › PET imaging of freely moving interacting rats.
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › PET imaging of freely moving interacting rats.
questionsmedicales.fr › Diagnostic › Techniques et procédures diagnostiques › Techniques de diagnostic radioisotopique › Scintigraphie › Tomoscintigraphie › Tomographie par émission de positons › PET imaging of freely moving interacting rats.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › PET imaging of freely moving interacting rats.
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Éveil › Vigilance › PET imaging of freely moving interacting rats.