Prophylaxis of peripartum haemorrhage using recombinant factor VIIa (rfVIIa) in pregnant women with congenital factor VII deficiency: A case report and literature review.
Coagulation disorders in pregnancy
Factor VII deficiency
Peripartum haemorrhage
Recombinant factor VIIa
Journal
European journal of obstetrics, gynecology, and reproductive biology
ISSN: 1872-7654
Titre abrégé: Eur J Obstet Gynecol Reprod Biol
Pays: Ireland
ID NLM: 0375672
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
10
10
2018
revised:
04
02
2019
accepted:
17
02
2019
pubmed:
5
3
2019
medline:
26
7
2019
entrez:
5
3
2019
Statut:
ppublish
Résumé
Congenital factor VII deficiency is a rare autosomal recessive disorder associated to different haemorrhagic manifestations. Labour and delivery may cause bleeding risk in patients with this coagulation deficit, thus it is appropriate to clarify whether prophylaxis of peripartum haemorrhage is necessary. To date, there are very few cases in scientific literature which report the management of women with congenital factor VII deficiency during labour, and a consensus for prophylaxis does not exist. In this manuscript we present the management of a 35 years old woman with factor VII deficiency, treated with recombinant factor VIIa before delivery, without haemorrhagic complications either for the woman and for the infant. Therefore, we present a review of similar cases managed with a peripartum prophylaxis with recombinant factor VIIa, and discuss its usefulness and effectiveness, in view of the severity of the deficit and the doses used.
Identifiants
pubmed: 30831446
pii: S0301-2115(19)30084-3
doi: 10.1016/j.ejogrb.2019.02.017
pii:
doi:
Substances chimiques
Recombinant Proteins
0
recombinant FVIIa
AC71R787OV
Factor VIIa
EC 3.4.21.21
Types de publication
Case Reports
Journal Article
Review
Langues
eng
Pagination
77-80Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.