Open Partial Horizontal Laryngectomies for T3⁻T4 Laryngeal Cancer: Prognostic Impact of Anterior vs. Posterior Laryngeal Compartmentalization.

conservative surgery laryngeal cancer open partial horizontal laryngectomy paraglottic space prognosis

Journal

Cancers
ISSN: 2072-6694
Titre abrégé: Cancers (Basel)
Pays: Switzerland
ID NLM: 101526829

Informations de publication

Date de publication:
01 Mar 2019
Historique:
received: 22 01 2019
revised: 23 02 2019
accepted: 24 02 2019
entrez: 6 3 2019
pubmed: 6 3 2019
medline: 6 3 2019
Statut: epublish

Résumé

Open partial horizontal laryngectomies (OPHLs) are well-established and oncologically safe procedures for intermediate⁻advanced laryngeal cancers (LC). T⁻N categories are well-known prognosticators: herein we tested if "anterior" vs. "posterior" tumor location (as defined in respect to the paraglottic space divided according to a plane passing through the arytenoid vocal process, perpendicular to the ipsilateral thyroid lamina) may represent an additional prognostic factor. We analyzed a retrospective cohort of 85 T3⁻4a glottic LCs, treated by Type II or III OPHL (according to the European Laryngological Society classification) from 2005 to 2017 at two academic institutions. Five-year overall survival (OS), disease-specific survivals (DSS), and recurrence-free survivals (RFS) were compared according to tumor location and pT category. Anterior and posterior tumors were 43.5% and 56.5%, respectively, 78.8% of lesions were T3 and 21.2% were T4a. Five-year OS, DSS, and RFS for T3 were 74.1%, 80.5%, and 63.4%, respectively, and for T4a 71.8%, 71.8%, and 43%, respectively (

Identifiants

DOI: 10.3390/cancers11030289 PMID: 30832209 PMC: PMC6468624
pubmed: 30832209
pii: cancers11030289
doi: 10.3390/cancers11030289
pmc: PMC6468624
pii:
doi:

Types de publication

Journal Article

Langues

eng

Références

Int J Radiat Oncol Biol Phys. 2001 Aug 1;50(5):1172-80
pubmed: 11483326
N Engl J Med. 2003 Nov 27;349(22):2091-8
pubmed: 14645636
Okajimas Folia Anat Jpn. 2004 Dec;81(5):85-92
pubmed: 15747874
Arch Otolaryngol Head Neck Surg. 2005 Jul;131(7):620-5
pubmed: 16027286
Head Neck. 2006 Jun;28(6):481-6
pubmed: 16470876
Otolaryngol Head Neck Surg. 2009 Jan;140(1):65-9
pubmed: 19130964
Head Neck. 2010 Jul;32(7):929-38
pubmed: 19953612
N Engl J Med. 1991 Jun 13;324(24):1685-90
pubmed: 2034244
Cancer Treat Rev. 2012 May;38(3):203-11
pubmed: 21764220
Otolaryngol Head Neck Surg. 2011 Nov;145(5):789-95
pubmed: 21791705
Head Neck. 2013 Apr;35(4):554-61
pubmed: 22495830
J Clin Oncol. 2013 Mar 1;31(7):845-52
pubmed: 23182993
Eur Arch Otorhinolaryngol. 2013 May;270(6):1927-32
pubmed: 23208526
Eur Arch Otorhinolaryngol. 2013 Aug;270(8):2275-81
pubmed: 23568037
Head Neck. 2014 May;36(5):652-9
pubmed: 23596018
Eur Arch Otorhinolaryngol. 2015 Mar;272(3):695-704
pubmed: 24682610
Eur Arch Otorhinolaryngol. 2014 Sep;271(9):2489-96
pubmed: 24691854
Laryngoscope. 2014 Nov;124(11):2561-7
pubmed: 24964904
Head Neck. 2016 Apr;38 Suppl 1:E333-40
pubmed: 25581514
Head Neck. 2016 Apr;38 Suppl 1:E649-57
pubmed: 25866908
Ann Otol Rhinol Laryngol. 2015 Nov;124(11):845-51
pubmed: 25991835
Dysphagia. 2015 Dec;30(6):686-94
pubmed: 26267541
Curr Opin Otolaryngol Head Neck Surg. 2016 Apr;24(2):135-9
pubmed: 26963672
Head Neck. 2016 Jul;38(7):1107-12
pubmed: 26970262
Oncol Lett. 2016 Apr;11(4):2595-2598
pubmed: 27073523
Eur J Surg Oncol. 2017 Jan;43(1):20-31
pubmed: 27320417
J Laryngol Otol. 2016 Oct;130(10):948-953
pubmed: 27774922
Eur Arch Otorhinolaryngol. 2018 Jan;275(1):27-38
pubmed: 29119321
Exp Ther Med. 2018 Mar;15(3):2786-2791
pubmed: 29456681
Clin Exp Otorhinolaryngol. 2018 Mar;11(1):1-8
pubmed: 29486540
Head Neck. 2018 Aug;40(8):1734-1742
pubmed: 29601122
Eur Arch Otorhinolaryngol. 2018 Jun;275(6):1601-1606
pubmed: 29610957
Head Neck. 2018 Sep;40(9):1897-1908
pubmed: 29756363
Eur Ann Otorhinolaryngol Head Neck Dis. 2018 Aug;135(4):249-253
pubmed: 29886093
Cancer Manag Res. 2018 Nov 08;10:5553-5558
pubmed: 30519103
Clin Otolaryngol. 2018 Dec 22;:null
pubmed: 30578588
Cancers (Basel). 2019 Jan 10;11(1):null
pubmed: 30634566
Clin Anat. 1996;9(4):244-51
pubmed: 8793218
Ann Otol Rhinol Laryngol. 1997 May;106(5):364-9
pubmed: 9153099
Otolaryngol Head Neck Surg. 1998 Jan;118(1):124-9
pubmed: 9450842
Arch Otolaryngol Head Neck Surg. 1998 Jun;124(6):637-40
pubmed: 9639472

Auteurs

Francesca Del Bon (F)

Department of Otorhinolaryngology-Head and Neck Surgery, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy. delbonfrancesca@gmail.com.

Cesare Piazza (C)

Department of Otorhinolaryngology, Maxillofacial and Thyroid Surgery, Fondazione IRCCS, National Cancer Institute of Milan, University of Milan, 20133 Milan, Italy. ceceplaza@libero.it.

Davide Lancini (D)

Department of Otorhinolaryngology-Head and Neck Surgery, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy. lancinidavide@gmail.com.
ORCID: 0000-0002-3525-3118

Alberto Paderno (A)

Department of Otorhinolaryngology-Head and Neck Surgery, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy. albpaderno@gmail.com.

Paolo Bosio (P)

Department of Otorhinolaryngology-Head and Neck Surgery, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy. paolo.bosio92@gmail.com.

Stefano Taboni (S)

Department of Otorhinolaryngology-Head and Neck Surgery, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy. stefanotaboni@gmail.com.

Riccardo Morello (R)

Department of Otorhinolaryngology-Head and Neck Surgery, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy. dott.riccardomorello@gmail.com.

Nausica Montalto (N)

Department of Otorhinolaryngology-Head and Neck Surgery, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy. nausica.montalto@gmail.com.

Francesco Missale (F)

Department of Otorhinolaryngology, Head and Neck Surgery, University of Genoa-IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy. missale.francesco@gmail.com.
ORCID: 0000-0002-5357-5348

Fabiola Incandela (F)

Department of Otorhinolaryngology, Maxillofacial and Thyroid Surgery, Fondazione IRCCS, National Cancer Institute of Milan, University of Milan, 20133 Milan, Italy. Fabiola.Incandela@istitutotumori.mi.it.

Filippo Marchi (F)

Department of Otorhinolaryngology, Head and Neck Surgery, University of Genoa-IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy. filippomarchi@hotmail.it.

Marta Filauro (M)

Department of Otorhinolaryngology, Head and Neck Surgery, University of Genoa-IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy. mfilauro@yahoo.com.

Alberto Deganello (A)

Department of Otorhinolaryngology-Head and Neck Surgery, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy. adeganello@hotmail.com.

Giorgio Peretti (G)

Department of Otorhinolaryngology, Head and Neck Surgery, University of Genoa-IRCCS Ospedale Policlinico San Martino, 16132 Genoa, Italy. giorgioperetti18@gmail.com.

Piero Nicolai (P)

Department of Otorhinolaryngology-Head and Neck Surgery, University of Brescia, Piazza Spedali Civili 1, 25123 Brescia, Italy. pieronicolai@virgilio.it.

Classifications MeSH