Genetics of Hypertension in African Americans and Others of African Descent.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
02 Mar 2019
Historique:
received: 05 01 2019
revised: 19 02 2019
accepted: 21 02 2019
entrez: 6 3 2019
pubmed: 6 3 2019
medline: 5 6 2019
Statut: epublish

Résumé

Hypertension is the leading cause of cardiovascular disease in the United States, affecting up to one-third of adults. When compared to other ethnic or racial groups in the United States, African Americans and other people of African descent show a higher incidence of hypertension and its related comorbidities; however, the genetics of hypertension in these populations has not been studied adequately. Several genes have been identified to play a role in the genetics of hypertension. They include genes regulating the renin-aldosterone-angiotensin system (RAAS), such as Sodium Channel Epithelial 1 Beta Subunit (

Identifiants

pubmed: 30832344
pii: ijms20051081
doi: 10.3390/ijms20051081
pmc: PMC6429313
pii:
doi:

Substances chimiques

ARMC5 protein, human 0
Armadillo Domain Proteins 0
CACNA1D protein, human 0
Calcium Channels, L-Type 0
Epithelial Sodium Channels 0
SCNN1B protein, human 0
Tumor Suppressor Proteins 0
G-Protein-Coupled Receptor Kinase 4 EC 2.7.11.16
GRK4 protein, human EC 2.7.11.16

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : National Institutes of Health
ID : 1ZIAHD008920-05

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Auteurs

Mihail Zilbermint (M)

Section on Endocrinology and Genetics, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, BG 31 RM 2A46, 31 Center Dr, Bethesda, MD 20892, USA. mihail.zilbermint@nih.gov.
Division of Endocrinology, Diabetes, and Metabolism, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. mihail.zilbermint@nih.gov.
Johns Hopkins Community Physicians at Suburban Hospital, Bethesda, MD 20814, USA. mihail.zilbermint@nih.gov.
Johns Hopkins University Carey Business School, Baltimore, MD 21202, USA. mihail.zilbermint@nih.gov.

Fady Hannah-Shmouni (F)

Section on Endocrinology and Genetics, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, BG 31 RM 2A46, 31 Center Dr, Bethesda, MD 20892, USA. Fady.Hannah-Shmouni@nih.gov.

Constantine A Stratakis (CA)

Section on Endocrinology and Genetics, The Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, BG 31 RM 2A46, 31 Center Dr, Bethesda, MD 20892, USA. stratakc@cc1.nichd.nih.gov.

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Classifications MeSH