Comparative Gene Expression Profiles in Parathyroid Adenoma and Normal Parathyroid Tissue.
RNA
endoplasmic reticulum
gene expression profiling
gene ontology
hyperparathyroidism
messenger
parathyroid adenoma
parathyroid glands
parathyroid hormone
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
02 Mar 2019
02 Mar 2019
Historique:
received:
29
01
2019
revised:
15
02
2019
accepted:
22
02
2019
entrez:
6
3
2019
pubmed:
6
3
2019
medline:
6
3
2019
Statut:
epublish
Résumé
Parathyroid adenoma is the main cause of primary hyperparathyroidism, which is characterized by enlarged parathyroid glands and excessive parathyroid hormone secretion. Here, we performed transcriptome analysis, comparing parathyroid adenomas with normal parathyroid gland tissue. RNA extracted from ten parathyroid adenoma and five normal parathyroid samples was sequenced, and differentially expressed genes (DEGs) were identified using strict cut-off criteria. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed using DEGs as the input, and protein-protein interaction (PPI) networks were constructed using Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and visualized in Cytoscape. Among DEGs identified in parathyroid adenomas (
Identifiants
pubmed: 30832348
pii: jcm8030297
doi: 10.3390/jcm8030297
pmc: PMC6463127
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : Seoul National University Hospital
ID : 04-2017-0280
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