A Lactic Acid Bacteria (LAB)-Based Vaccine Candidate for Human Norovirus.
Animals
Antibodies, Viral
/ blood
Caliciviridae Infections
/ prevention & control
DNA, Bacterial
/ isolation & purification
Feces
/ microbiology
Gastroenteritis
/ prevention & control
Gastrointestinal Tract
/ microbiology
Genetic Vectors
Germ-Free Life
Lactococcus lactis
Norovirus
/ genetics
Swine
Viral Structural Proteins
/ genetics
Viral Vaccines
/ immunology
VP1
gnotobiotic piglet
human norovirus
lactic acid bacteria
vaccine
Journal
Viruses
ISSN: 1999-4915
Titre abrégé: Viruses
Pays: Switzerland
ID NLM: 101509722
Informations de publication
Date de publication:
02 03 2019
02 03 2019
Historique:
received:
12
01
2019
revised:
15
02
2019
accepted:
20
02
2019
entrez:
6
3
2019
pubmed:
6
3
2019
medline:
19
9
2019
Statut:
epublish
Résumé
Human noroviruses (HuNoVs) are responsible for more than 95% of the non-bacterial acute gastroenteritis epidemics in the world. The CDC estimates that every year 21 million individuals suffer from HuNoV-induced gastroenteritis in the United States. Currently, there is no FDA-approved vaccine for HuNoVs. Development of an effective vaccine has been hampered by the lack of an efficient cell culture system for HuNoVs and a suitable small animal model for pathogenesis study. In this study, we developed lactic acid bacteria (LAB) as a vector to deliver HuNoV antigen. A LAB strain (
Identifiants
pubmed: 30832363
pii: v11030213
doi: 10.3390/v11030213
pmc: PMC6466309
pii:
doi:
Substances chimiques
Antibodies, Viral
0
DNA, Bacterial
0
Viral Structural Proteins
0
Viral Vaccines
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : R01 AI123661
Pays : United States
Organisme : NIH HHS
ID : AI12366
Pays : United States
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