Inhibited autophagy may contribute to heme toxicity in cardiomyoblast cells.

Animals Autophagy Cell Survival Heme Oxygenase-1 / metabolism Hemin / metabolism Myoblasts, Cardiac / cytology Oxidative Stress Protoporphyrins / metabolism Rats Reactive Oxygen Species / metabolism
Autophagy Cardiomyocytes Heme Heme oxygenase-1 Toxicity

Journal

Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516

Informations de publication

Date de publication:
16 04 2019
Historique:
received: 21 02 2019
accepted: 25 02 2019
pubmed: 6 3 2019
medline: 14 1 2020
entrez: 6 3 2019
Statut: ppublish

Résumé

Several groups have demonstrated that induction of heme-oxygenase-1 (HO-1) could protect the myocardium against ischemic events; however, heme accumulation could lead to toxicity. The aim of the present study was to investigate the role of autophagy in heme toxicity. H9c2 cardiomyoblast cells were treated with different dose of hemin or cobalt-protoporphyrin IX (CoPP

Identifiants

DOI: 10.1016/j.bbrc.2019.02.140 PMID: 30833080
pubmed: 30833080
pii: S0006-291X(19)30341-9
doi: 10.1016/j.bbrc.2019.02.140
pii:
doi:

Substances chimiques

Protoporphyrins 0
Reactive Oxygen Species 0
cobaltiprotoporphyrin 63AAN3JDZE
Hemin 743LRP9S7N
Heme Oxygenase-1 EC 1.14.14.18

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

732-738

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Alexandra Gyongyosi (A)

Department of Pharmacology, Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary.

Kitti Szoke (K)

Department of Pharmacology, Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary.

Ferenc Fenyvesi (F)

Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary.

Zsolt Fejes (Z)

Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Ildiko Beke Debreceni (IB)

Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Bela Nagy (B)

Department of Laboratory Medicine, Faculty of Medicine, University of Debrecen, Debrecen, Hungary.

Arpad Tosaki (A)

Department of Pharmacology, Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary.

Istvan Lekli (I)

Department of Pharmacology, Faculty of Pharmacy, University of Debrecen, Debrecen, Hungary. Electronic address: lekli.istvan@pharm.unideb.hu.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Inhibited autophagy may contribute to heme...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Autophagie › Inhibited autophagy may contribute to heme...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Survie cellulaire › Inhibited autophagy may contribute to heme...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxygénases › Mixed function oxygenases › Heme oxygenase (decyclizing) › Heme oxygenase-1 › Inhibited autophagy may contribute to heme...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Porphyrines › Métalloporphyrines › Hème › Hémine › Inhibited autophagy may contribute to heme...
questionsmedicales.fr › Cellules › Cellules souches › Myoblastes › Myoblastes cardiaques › Inhibited autophagy may contribute to heme...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › Stress oxydatif › Inhibited autophagy may contribute to heme...
questionsmedicales.fr › Facteurs biologiques › Pigments biologiques › Porphyrines › Protoporphyrines › Inhibited autophagy may contribute to heme...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Inhibited autophagy may contribute to heme...
questionsmedicales.fr › Produits chimiques inorganiques › Composés de l'oxygène › Espèces réactives de l'oxygène › Inhibited autophagy may contribute to heme...