miR-132 suppresses transcription of ribosomal proteins to promote protective Th1 immunity.


Journal

EMBO reports
ISSN: 1469-3178
Titre abrégé: EMBO Rep
Pays: England
ID NLM: 100963049

Informations de publication

Date de publication:
04 2019
Historique:
received: 20 06 2018
revised: 01 02 2019
accepted: 06 02 2019
pubmed: 6 3 2019
medline: 1 5 2020
entrez: 6 3 2019
Statut: ppublish

Résumé

Determining the mechanisms that distinguish protective immunity from pathological chronic inflammation remains a fundamental challenge. miR-132 has been shown to play largely immunoregulatory roles in immunity; however, its role in CD4

Identifiants

pubmed: 30833344
pii: embr.201846620
doi: 10.15252/embr.201846620
pmc: PMC6446204
mid: EMS84321
pii:
doi:

Substances chimiques

Cytokines 0
MIRN132 microRNA, mouse 0
MicroRNAs 0
Ribosomal Proteins 0
Transcription Factor TFIID 0
p300-CBP Transcription Factors EC 2.3.1.48

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Medical Research Council
ID : G1000230
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L008505/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/N009185/1
Pays : United Kingdom

Informations de copyright

© 2019 The Authors.

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Auteurs

James P Hewitson (JP)

Centre for Immunology and Infection and York Biomedical Research Institute, Hull York Medical School and Department of Biology, University of York, York, UK.

Kunal M Shah (KM)

Centre of Molecular Oncology, Barts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University London, London, UK.

Najmeeyah Brown (N)

Centre for Immunology and Infection and York Biomedical Research Institute, Hull York Medical School and Department of Biology, University of York, York, UK.

Paul Grevitt (P)

Centre of Molecular Oncology, Barts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University London, London, UK.

Sofia Hain (S)

Centre for Immunology and Infection and York Biomedical Research Institute, Hull York Medical School and Department of Biology, University of York, York, UK.

Katherine Newling (K)

Genomics and Bioinformatics Laboratory, Bioscience Technology Facility, Department of Biology, University of York, York, UK.

Tyson V Sharp (TV)

Centre of Molecular Oncology, Barts Cancer Institute, John Vane Science Centre, Charterhouse Square, Queen Mary University London, London, UK.

Paul M Kaye (PM)

Centre for Immunology and Infection and York Biomedical Research Institute, Hull York Medical School and Department of Biology, University of York, York, UK.

Dimitris Lagos (D)

Centre for Immunology and Infection and York Biomedical Research Institute, Hull York Medical School and Department of Biology, University of York, York, UK dimitris.lagos@york.ac.uk.

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