Base excision repair deficiency signatures implicate germline and somatic

Age of Onset Breast Neoplasms / genetics Carcinoma, Pancreatic Ductal / genetics DNA Glycosylases / deficiency Female Germ-Line Mutation Humans Loss of Heterozygosity Middle Aged Mutation Pancreatic Neoplasms / genetics Proto-Oncogene Proteins p21(ras) / genetics

neoplasm of the breast neoplasm of the pancreas pancreatic adenocarcinoma

Journal

Cold Spring Harbor molecular case studies

ISSN: 2373-2873

Titre abrégé: Cold Spring Harb Mol Case Stud

Pays: United States

ID NLM: 101660017

Informations de publication

Date de publication:
04 2019

Historique:

received: 15 11 2018

accepted: 17 02 2019

pubmed: 6 3 2019

medline: 9 4 2020

entrez: 6 3 2019

Statut: epublish

Résumé

We report a case of early-onset pancreatic ductal adenocarcinoma in a patient harboring biallelic

Identifiants

DOI: 10.1101/mcs.a003681 PMID: 30833417 PMC: PMC6549570

pubmed: 30833417

pii: mcs.a003681

doi: 10.1101/mcs.a003681

pmc: PMC6549570

pii:

doi:

Substances chimiques

KRAS protein, human 0

DNA Glycosylases EC 3.2.2.-

mutY adenine glycosylase EC 3.2.2.-

Proto-Oncogene Proteins p21(ras) EC 3.6.5.2

Banques de données

ClinicalTrials.gov

['NCT02155621']

Types de publication

Case Reports Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

Subventions

Organisme : CIHR

Pays : Canada

Informations de copyright

Références

Nat Genet. 2015 Jun;47(6):668-71

pubmed: 25938944

Cancer Genet. 2015 Jul-Aug;208(7-8):390-5

pubmed: 26056087

Fam Cancer. 2016 Apr;15(2):261-5

pubmed: 26684191

Bioinformatics. 2017 Aug 1;33(15):2402-2404

pubmed: 28369222

Nucleic Acids Res. 2017 Jan 4;45(D1):D777-D783

pubmed: 27899578

EBioMedicine. 2017 Jun;20:39-49

pubmed: 28551381

Breast Cancer Res Treat. 2010 Dec;124(3):635-41

pubmed: 20191381

Nature. 2013 Aug 22;500(7463):415-21

pubmed: 23945592

DNA Repair (Amst). 2007 Mar 1;6(3):274-9

pubmed: 17161978

Cancer Res. 2007 Jul 15;67(14):6599-604

pubmed: 17638869

DNA Repair (Amst). 2002 Nov 3;1(11):881-93

pubmed: 12531017

Nature. 2017 Mar 2;543(7643):65-71

pubmed: 28199314

Int J Cancer. 2005 Aug 10;116(1):73-7

pubmed: 15761860

Genome Biol. 2010;11(8):R82

pubmed: 20696054

Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4156-61

pubmed: 10725358

Br J Cancer. 2004 Apr 19;90(8):1591-3

pubmed: 15083190

Hum Mutat. 2011 May;32(5):557-63

pubmed: 21520333

J Biol Chem. 1992 Jan 5;267(1):166-72

pubmed: 1730583

Eur J Hum Genet. 2014 Jul;22(7):923-9

pubmed: 23361220

Proc Natl Acad Sci U S A. 1999 Nov 9;96(23):13300-5

pubmed: 10557315

Pancreatology. 2009;9(6):793-6

pubmed: 20110747

Genes Cells. 2006 Jul;11(7):767-78

pubmed: 16824196

Nucleic Acids Res. 2016 Jan 4;44(D1):D862-8

pubmed: 26582918

Med Oncol. 2016 Apr;33(4):32

pubmed: 26927447

Nature. 2016 Mar 3;531(7592):47-52

pubmed: 26909576

Fam Cancer. 2012 Sep;11(3):329-35

pubmed: 22371070

Nat Commun. 2018 May 1;9(1):1746

pubmed: 29717118

Nature. 2016 Aug 17;536(7616):285-91

pubmed: 27535533

J Pathol. 2017 May;242(1):10-15

pubmed: 28127763

Clin Cancer Res. 2017 Dec 15;23(24):7521-7530

pubmed: 29246904

Proc Natl Acad Sci U S A. 2001 Sep 25;98(20):11456-61

pubmed: 11572992

Hum Mutat. 2018 Sep;39(9):1214-1225

pubmed: 29900613

DNA Repair (Amst). 2010 May 4;9(5):542-50

pubmed: 20197241

Cancer Res. 2003 Mar 1;63(5):902-5

pubmed: 12615700

Int J Cancer. 2011 Nov 1;129(9):2256-62

pubmed: 21171015

Bioinformatics. 2012 Jul 15;28(14):1811-7

pubmed: 22581179

BMC Med Genomics. 2018 Sep 10;11(1):79

pubmed: 30200994

Genome Res. 2012 Oct;22(10):1995-2007

pubmed: 22637570

Hered Cancer Clin Pract. 2014 Dec 12;12(1):21

pubmed: 25937855

Brief Bioinform. 2013 Mar;14(2):178-92

pubmed: 22517427

NPJ Precis Oncol. 2018 Mar 19;2(1):8

pubmed: 29872726