Microbial Colonization Coordinates the Pathogenesis of a Klebsiella pneumoniae Infant Isolate.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
04 03 2019
04 03 2019
Historique:
received:
20
07
2018
accepted:
28
01
2019
entrez:
6
3
2019
pubmed:
6
3
2019
medline:
23
9
2020
Statut:
epublish
Résumé
Enterobacteriaceae are among the first colonizers of neonate intestine. Members of this family, such as Escherichia and Klebsiella, are considered pathobionts and as such are capable of inducing local and systemic disease under specific colonization circumstances. Interplay between developing microbiota and pathogenic function of pathobionts are poorly understood. In this study, we investigate the functional interaction between various colonization patterns on an early colonizer, K. pneumoniae. K. pneumoniae 51-5 was isolated from stool of a healthy, premature infant, and found to contain the genotoxin island pks associated with development of colorectal cancer. Using intestinal epithelial cells, macrophages, and primary splenocytes, we demonstrate K. pneumoniae 51-5 upregulates expression of proinflammatory genes in vitro. Gnotobiotic experiments in Il10
Identifiants
pubmed: 30833613
doi: 10.1038/s41598-019-39887-8
pii: 10.1038/s41598-019-39887-8
pmc: PMC6399262
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3380Subventions
Organisme : NCI NIH HHS
ID : R01 CA214005
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK073338
Pays : United States
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