Hedgehog signaling in the airway epithelium of patients with chronic obstructive pulmonary disease.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
04 03 2019
04 03 2019
Historique:
received:
11
09
2018
accepted:
21
01
2019
entrez:
6
3
2019
pubmed:
6
3
2019
medline:
21
10
2020
Statut:
epublish
Résumé
Genome-wide association studies have linked gene variants of the receptor patched homolog 1 (PTCH1) with chronic obstructive pulmonary disease (COPD). However, its biological role in the disease is unclear. Our objective was to determine the expression pattern and biological role of PTCH1 in the lungs of patients with COPD. Airway epithelial-specific PTCH1 protein expression and epithelial morphology were assessed in lung tissues of control and COPD patients. PTCH1 mRNA expression was measured in bronchial epithelial cells obtained from individuals with and without COPD. The effects of PTCH1 siRNA knockdown on epithelial repair and mucous expression were evaluated using human epithelial cell lines. Ptch1
Identifiants
pubmed: 30833624
doi: 10.1038/s41598-019-40045-3
pii: 10.1038/s41598-019-40045-3
pmc: PMC6399332
doi:
Substances chimiques
PTCH1 protein, human
0
Patched-1 Receptor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3353Références
Eur Respir J. 2018 Jul 19;52(1):
pubmed: 30002103
J Clin Invest. 2009 Oct;119(10):2914-24
pubmed: 19759516
Nature. 2015 Oct 22;526(7574):578-82
pubmed: 26436454
J Allergy Clin Immunol. 2014 Apr;133(4):1142-8
pubmed: 24679471
Am J Respir Crit Care Med. 2016 Apr 15;193(8):825-34
pubmed: 26599602
Nat Struct Mol Biol. 2009 Jul;16(7):691-7
pubmed: 19561609
PLoS One. 2014 Jun 25;9(6):e100633
pubmed: 24964096
Int J Chron Obstruct Pulmon Dis. 2015 Aug 04;10:1515-24
pubmed: 26346976
Nat Med. 1998 May;4(5):619-22
pubmed: 9585239
Hum Mol Genet. 2012 Mar 15;21(6):1325-35
pubmed: 22140090
Chest. 2009 Feb;135(2):505-512
pubmed: 19201713
Am J Respir Cell Mol Biol. 2011 Aug;45(2):246-52
pubmed: 20935193
BMC Genet. 2015 Dec 03;16:138
pubmed: 26634245
Eur Respir J. 2017 Mar 6;49(3):
pubmed: 28182564
J Biol Chem. 2005 Apr 22;280(16):15700-8
pubmed: 15691835
PLoS Genet. 2009 Mar;5(3):e1000421
pubmed: 19300482
Science. 1997 Aug 22;277(5329):1109-13
pubmed: 9262482
Development. 2007 May;134(10):1977-89
pubmed: 17442700
Front Cell Neurosci. 2014 Mar 11;8:77
pubmed: 24653675
BMJ. 2017 Sep 25;358:j3772
pubmed: 28947632
PLoS One. 2014 Aug 28;9(8):e106106
pubmed: 25166306
Sci Rep. 2017 Apr 11;7:46166
pubmed: 28397820
Am J Physiol Lung Cell Mol Physiol. 2004 Aug;287(2):L420-7
pubmed: 15121636
Am J Pathol. 2012 Dec;181(6):2126-37
pubmed: 23031257
N Engl J Med. 2011 Oct 27;365(17):1567-75
pubmed: 22029978
Am J Physiol Lung Cell Mol Physiol. 2012 Dec 1;303(11):L978-90
pubmed: 23023967
Respir Res. 2016 Nov 25;17(1):159
pubmed: 27887617
PLoS One. 2015 Mar 27;10(3):e0121579
pubmed: 25815884
PLoS One. 2011 Feb 03;6(2):e16798
pubmed: 21304817
Am J Respir Cell Mol Biol. 2015 Jan;52(1):1-13
pubmed: 25068457
PLoS One. 2013 Jul 30;8(7):e70220
pubmed: 23936167
N Engl J Med. 2004 Jun 24;350(26):2645-53
pubmed: 15215480
Lancet Respir Med. 2015 Oct;3(10):782-95
pubmed: 26404118
Genes Dev. 2008 Oct 1;22(19):2651-63
pubmed: 18832070
Biol Open. 2016 Jan 06;5(2):112-21
pubmed: 26740570
Proc Natl Acad Sci U S A. 1988 Aug;85(16):5951-5
pubmed: 2457904
J Allergy Clin Immunol. 2009 Nov;124(5):913-20.e1-7
pubmed: 19895983
Nat Genet. 2017 Mar;49(3):426-432
pubmed: 28166215
Hum Genet. 2013 Apr;132(4):431-41
pubmed: 23299987
Am J Physiol Lung Cell Mol Physiol. 2011 Mar;300(3):L414-21
pubmed: 21224214
J Clin Invest. 2015 May;125(5):2021-31
pubmed: 25866971
Lancet Respir Med. 2014 Mar;2(3):214-25
pubmed: 24621683
J Immunol. 2004 Nov 15;173(10):6384-92
pubmed: 15528378
Thorax. 2013 Feb;68(2):131-41
pubmed: 23099361
Int J Chron Obstruct Pulmon Dis. 2017 Dec 19;13:11-27
pubmed: 29296079
Mol Cell Biol. 2007 Oct;27(19):6933-47
pubmed: 17646388
J Immunol. 2011 Jul 1;187(1):222-9
pubmed: 21622856
Thorax. 2012 Jun;67(6):488-95
pubmed: 22167364
Mucosal Immunol. 2018 Sep;11(5):1306-1315
pubmed: 29867080
J Immunol. 2013 Mar 15;190(6):2641-9
pubmed: 23408837