Reduced habit-driven errors in Parkinson's Disease.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
04 03 2019
Historique:
received: 03 08 2018
accepted: 11 12 2018
entrez: 6 3 2019
pubmed: 6 3 2019
medline: 22 9 2020
Statut: epublish

Résumé

Parkinson's Disease can be understood as a disorder of motor habits. A prediction of this theory is that early stage Parkinson's patients will display fewer errors caused by interference from previously over-learned behaviours. We test this prediction in the domain of skilled typing, where actions are easy to record and errors easy to identify. We describe a method for categorizing errors as simple motor errors or habit-driven errors. We test Spanish and English participants with and without Parkinson's, and show that indeed patients make fewer habit errors than healthy controls, and, further, that classification of error type increases the accuracy of discriminating between patients and healthy controls. As well as being a validation of a theory-led prediction, these results offer promise for automated, enhanced and early diagnosis of Parkinson's Disease.

Identifiants

pubmed: 30833640
doi: 10.1038/s41598-019-39294-z
pii: 10.1038/s41598-019-39294-z
pmc: PMC6399280
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3423

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Auteurs

Colin Bannard (C)

Department of Psychological Sciences, University of Liverpool, Liverpool, UK. cbannard@liverpool.ac.uk.

Mariana Leriche (M)

Department of Anatomy, University of Otago, Dunedin, New Zealand.

Oliver Bandmann (O)

Sheffield Institute for Translational Neuroscience (SITraN), University of Sheffield, Sheffield, UK.

Christopher H Brown (CH)

Department of Linguistics, University of Texas at Austin, Austin, USA.

Elisa Ferracane (E)

Department of Linguistics, University of Texas at Austin, Austin, USA.

Álvaro Sánchez-Ferro (Á)

HM Hospitales, Centre for Integrative Neuroscience AC, Hospital Universitario HM Puerta del Sur, Mostoles and CEU San Pablo University. Center for Networked Biomedical Research on Neurodegenerative Diseases, Institute Carlos III, Madrid, Spain.

José Obeso (J)

HM Hospitales, Centre for Integrative Neuroscience AC, Hospital Universitario HM Puerta del Sur, Mostoles and CEU San Pablo University. Center for Networked Biomedical Research on Neurodegenerative Diseases, Institute Carlos III, Madrid, Spain.

Peter Redgrave (P)

Department of Psychology, University of Sheffield, Sheffield, UK.

Tom Stafford (T)

Department of Psychology, University of Sheffield, Sheffield, UK.

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