Rapid, biphasic CRF neuronal responses encode positive and negative valence.
Journal
Nature neuroscience
ISSN: 1546-1726
Titre abrégé: Nat Neurosci
Pays: United States
ID NLM: 9809671
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
10
04
2018
accepted:
18
01
2019
pubmed:
6
3
2019
medline:
22
5
2019
entrez:
6
3
2019
Statut:
ppublish
Résumé
Corticotropin-releasing factor (CRF) that is released from the paraventricular nucleus (PVN) of the hypothalamus is essential for mediating stress response by activating the hypothalamic-pituitary-adrenal axis. CRF-releasing PVN neurons receive inputs from multiple brain regions that convey stressful events, but their neuronal dynamics on the timescale of behavior remain unknown. Here, our recordings of PVN CRF neuronal activity in freely behaving mice revealed that CRF neurons are activated immediately by a range of aversive stimuli. By contrast, CRF neuronal activity starts to drop within a second of exposure to appetitive stimuli. Optogenetic activation or inhibition of PVN CRF neurons was sufficient to induce a conditioned place aversion or preference, respectively. Furthermore, conditioned place aversion or preference induced by natural stimuli was significantly decreased by manipulating PVN CRF neuronal activity. Together, these findings suggest that the rapid, biphasic responses of PVN CRF neurons encode the positive and negative valences of stimuli.
Identifiants
pubmed: 30833699
doi: 10.1038/s41593-019-0342-2
pii: 10.1038/s41593-019-0342-2
pmc: PMC6668342
mid: NIHMS1519156
doi:
Substances chimiques
Corticotropin-Releasing Hormone
9015-71-8
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
576-585Subventions
Organisme : NIDDK NIH HHS
ID : R01 DK106636
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH101377
Pays : United States
Commentaires et corrections
Type : CommentIn
Type : CommentIn
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