SLAM receptors foster iNKT cell development by reducing TCR signal strength after positive selection.
Animals
Cell Proliferation
Cell Survival
Costimulatory and Inhibitory T-Cell Receptors
/ metabolism
Humans
Mice
Mice, Knockout
Natural Killer T-Cells
/ enzymology
Protein Tyrosine Phosphatase, Non-Receptor Type 6
/ genetics
Proto-Oncogene Proteins c-bcl-2
/ metabolism
Proto-Oncogene Proteins c-fyn
/ metabolism
Receptors, Antigen, T-Cell
/ immunology
Signal Transduction
Signaling Lymphocytic Activation Molecule Associated Protein
/ genetics
Signaling Lymphocytic Activation Molecule Family
/ genetics
Journal
Nature immunology
ISSN: 1529-2916
Titre abrégé: Nat Immunol
Pays: United States
ID NLM: 100941354
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
16
08
2018
accepted:
25
01
2019
pubmed:
6
3
2019
medline:
20
4
2019
entrez:
6
3
2019
Statut:
ppublish
Résumé
Invariant natural killer T cells (iNKT cells) develop through an incompletely understood process that requires positive selection by CD4
Identifiants
pubmed: 30833791
doi: 10.1038/s41590-019-0334-0
pii: 10.1038/s41590-019-0334-0
doi:
Substances chimiques
Costimulatory and Inhibitory T-Cell Receptors
0
Proto-Oncogene Proteins c-bcl-2
0
Receptors, Antigen, T-Cell
0
SLAMF6 protein, human
0
Sh2d1a protein, mouse
0
Signaling Lymphocytic Activation Molecule Associated Protein
0
Signaling Lymphocytic Activation Molecule Family
0
Slamf6 protein, mouse
0
Proto-Oncogene Proteins c-fyn
EC 2.7.10.2
Protein Tyrosine Phosphatase, Non-Receptor Type 6
EC 3.1.3.48
Ptpn6 protein, mouse
EC 3.1.3.48
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
447-457Commentaires et corrections
Type : CommentIn