Characterization of a subgroup of non-type 2 asthma with cow's milk hypersensitivity in young subjects.
Journal
Clinical and translational allergy
ISSN: 2045-7022
Titre abrégé: Clin Transl Allergy
Pays: England
ID NLM: 101576043
Informations de publication
Date de publication:
2019
2019
Historique:
received:
05
12
2018
accepted:
31
01
2019
entrez:
6
3
2019
pubmed:
6
3
2019
medline:
6
3
2019
Statut:
epublish
Résumé
Asthma with atopy is often characterized by type 2 inflammation but less progress has been made in defining non-type 2 asthma. We have previously identified a subgroup of young non-atopic asthmatics with perceived food hypersensitivity and poor asthma control. Our aim was to further characterize this subgroup of non-type 2 asthmatics, including the use of a broad panel of inflammation-related proteins. Sex- and age-matched subjects (10-35 years old) were divided into three groups with regard to history of asthma and atopy: non-atopic asthmatics with perceived cow's milk hypersensitivity but with IgE antibodies < 0.35 kU NAA had lower FeNO ( In a subgroup of non-atopic young asthmatics with perceived cow's milk hypersensitivity we observed poor asthma-related quality of life, airway hyperresponsiveness, and clinically relevant non-type 2 inflammation. MMP-1 was elevated in this group, which deserves further studies.
Sections du résumé
BACKGROUND
BACKGROUND
Asthma with atopy is often characterized by type 2 inflammation but less progress has been made in defining non-type 2 asthma. We have previously identified a subgroup of young non-atopic asthmatics with perceived food hypersensitivity and poor asthma control.
OBJECTIVE
OBJECTIVE
Our aim was to further characterize this subgroup of non-type 2 asthmatics, including the use of a broad panel of inflammation-related proteins.
METHODS
METHODS
Sex- and age-matched subjects (10-35 years old) were divided into three groups with regard to history of asthma and atopy: non-atopic asthmatics with perceived cow's milk hypersensitivity but with IgE antibodies < 0.35 kU
RESULTS
RESULTS
NAA had lower FeNO (
CONCLUSION
CONCLUSIONS
In a subgroup of non-atopic young asthmatics with perceived cow's milk hypersensitivity we observed poor asthma-related quality of life, airway hyperresponsiveness, and clinically relevant non-type 2 inflammation. MMP-1 was elevated in this group, which deserves further studies.
Identifiants
pubmed: 30834110
doi: 10.1186/s13601-019-0250-2
pii: 250
pmc: PMC6385459
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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