Minor Isozymes Tailor Yeast Metabolism to Carbon Availability.
cerevisiae
duplicates
genomics
isozymes
metabolomics
paralogs
systems biology
transcriptomics
yeast
Journal
mSystems
ISSN: 2379-5077
Titre abrégé: mSystems
Pays: United States
ID NLM: 101680636
Informations de publication
Date de publication:
Historique:
received:
15
08
2018
accepted:
21
01
2019
entrez:
6
3
2019
pubmed:
6
3
2019
medline:
6
3
2019
Statut:
epublish
Résumé
Isozymes are enzymes that differ in sequence but catalyze the same chemical reactions. Despite their apparent redundancy, isozymes are often retained over evolutionary time, suggesting that they contribute to fitness. We developed an unsupervised computational method for identifying environmental conditions under which isozymes are likely to make fitness contributions. This method analyzes published gene expression data to find specific experimental perturbations that induce differential isozyme expression. In yeast, we found that isozymes are strongly enriched in the pathways of central carbon metabolism and that many isozyme pairs show anticorrelated expression during the respirofermentative shift. Building on these observations, we assigned function to two minor central carbon isozymes, aconitase 2 (
Identifiants
pubmed: 30834327
doi: 10.1128/mSystems.00170-18
pii: mSystems00170-18
pmc: PMC6392091
pii:
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM071966
Pays : United States
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