New treatments for hyperkalaemia: clinical use in cardiology.
Heart failure
Hyperkalaemia
Hypertension
Patiromer
Sodium zirconium cyclosilicate
Journal
European heart journal supplements : journal of the European Society of Cardiology
ISSN: 1520-765X
Titre abrégé: Eur Heart J Suppl
Pays: England
ID NLM: 100886647
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
entrez:
7
3
2019
pubmed:
7
3
2019
medline:
7
3
2019
Statut:
ppublish
Résumé
Hyperkalaemia causes significant burden, and even mild hyperkalaemia has been independently associated with increased morbidity and mortality. Patients with chronic disease states, such as heart failure, hypertension, chronic kidney disease and diabetes mellitus, are increasingly susceptible to the development of hyperkalaemia. Options for management of hyperkalaemia had mainly been limited to short-term, temporizing methods with focus on rapid achievement of normokalaemia. Until recently, there was a lack of safe, efficacious and well-tolerated therapies for long-term management. Two novel potassium binders, patiromer and sodium zirconium cyclosilicate, have recently been approved by the US Food and Drug Administration for the management of hyperkalaemia. This review discusses these potassium binders with focus largely on the clinical implications of these agents in patients with chronic cardiovascular conditions.
Identifiants
pubmed: 30837804
doi: 10.1093/eurheartj/suy031
pii: suy031
pmc: PMC6392415
doi:
Types de publication
Journal Article
Langues
eng
Pagination
A41-A47Subventions
Organisme : NIGMS NIH HHS
ID : U54 GM115428
Pays : United States
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