Overexpression of Mitochondrial Ligases Reverses Rotenone-Induced Effects in a
apoptosis
autophagy
mul1
neurodegeneration
park
synapses
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2019
2019
Historique:
received:
03
12
2018
accepted:
25
01
2019
entrez:
7
3
2019
pubmed:
7
3
2019
medline:
7
3
2019
Statut:
epublish
Résumé
Mul1 and Park are two major mitochondrial ligases responsible for mitophagy. Damaged mitochondria that cannot be removed are a source of an increased level of free radicals, which in turn can destructively affect other cell organelles as well as entire cells. One of the toxins that damages mitochondria is rotenone, a neurotoxin that after exposure displays symptoms typical of Parkinson's disease. In the present study, we showed that overexpressing genes encoding mitochondrial ligases protects neurons during treatment with rotenone.
Identifiants
pubmed: 30837828
doi: 10.3389/fnins.2019.00094
pmc: PMC6382686
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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