Older age and obesity are associated with increased airway closure in response to methacholine in patients with asthma.
Administration, Inhalation
Adolescent
Adult
Age Factors
Asthma
/ complications
Bronchial Provocation Tests
Bronchoconstrictor Agents
/ administration & dosage
Child
Female
Forced Expiratory Volume
/ drug effects
Humans
Male
Methacholine Chloride
/ administration & dosage
Middle Aged
Obesity
/ complications
Vital Capacity
/ drug effects
Young Adult
airway closure
airway hyperresponsiveness
asthma
methacholine
obesity
Journal
Respirology (Carlton, Vic.)
ISSN: 1440-1843
Titre abrégé: Respirology
Pays: Australia
ID NLM: 9616368
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
13
02
2018
revised:
29
11
2018
accepted:
02
01
2019
pubmed:
7
3
2019
medline:
28
4
2020
entrez:
7
3
2019
Statut:
ppublish
Résumé
The reduction of forced expiratory volume in 1 s (FEV We used the methacholine challenge data from participants in five studies of the ALA-ACRC to determine the closing index, defined as the contribution of airway closure to the decrease in FEV There were a total of 936 participants with asthma, among whom the median closing index was 0.67 relative to that of a published healthy population of 0.54. A higher closing index was associated with increased age (10-year increments) (0.04, 95% CI = 0.02, 0.05, P < 0.005) and obesity (0.07, 95% CI = 0.03, 0.10, P < 0.001). There was no association between the closing index and asthma control. Our findings confirm that airway closure in response to methacholine occurs in a large, diverse population of asthmatic participants, and that increased airway closure is associated with older age and obesity. These findings suggest that therapies targeting airway closure may be important in patients with a high closing index.
Sections du résumé
BACKGROUND AND OBJECTIVE
The reduction of forced expiratory volume in 1 s (FEV
METHODS
We used the methacholine challenge data from participants in five studies of the ALA-ACRC to determine the closing index, defined as the contribution of airway closure to the decrease in FEV
RESULTS
There were a total of 936 participants with asthma, among whom the median closing index was 0.67 relative to that of a published healthy population of 0.54. A higher closing index was associated with increased age (10-year increments) (0.04, 95% CI = 0.02, 0.05, P < 0.005) and obesity (0.07, 95% CI = 0.03, 0.10, P < 0.001). There was no association between the closing index and asthma control.
CONCLUSION
Our findings confirm that airway closure in response to methacholine occurs in a large, diverse population of asthmatic participants, and that increased airway closure is associated with older age and obesity. These findings suggest that therapies targeting airway closure may be important in patients with a high closing index.
Identifiants
pubmed: 30838750
doi: 10.1111/resp.13496
pmc: PMC9511501
mid: NIHMS1824138
doi:
Substances chimiques
Bronchoconstrictor Agents
0
Methacholine Chloride
0W5ETF9M2K
Types de publication
Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
638-645Subventions
Organisme : NHLBI NIH HHS
ID : U01 HL108730
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL080450
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL089464
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL089510
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL072968
Pays : United States
Organisme : NEI NIH HHS
ID : UG1 EY028091
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL080433
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 Asian Pacific Society of Respirology.
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