A Stretchable and Flexible Cardiac Tissue-Electronics Hybrid Enabling Multiple Drug Release, Sensing, and Stimulation.
cardiac patches
cardiac tissue engineering
controlled release
electrospun fiber scaffolds
microelectronics
Journal
Small (Weinheim an der Bergstrasse, Germany)
ISSN: 1613-6829
Titre abrégé: Small
Pays: Germany
ID NLM: 101235338
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
27
12
2018
revised:
17
02
2019
pubmed:
7
3
2019
medline:
15
8
2020
entrez:
7
3
2019
Statut:
ppublish
Résumé
Replacement of the damaged scar tissue created by a myocardial infarction is the goal of cardiac tissue engineering. However, once the implanted tissue is in place, monitoring its function is difficult and involves indirect methods, while intervention necessarily requires an invasive procedure and available medical attention. To overcome this, methods of integrating electronic components into engineered tissues have been recently presented. These allow for remote monitoring of tissue function as well as intervention through stimulation and controlled drug release. Here, an improved hybrid microelectronic tissue construct capable of withstanding the dynamic environment of the beating heart without compromising electronic or mechanical functionality is reported. While the reported system is enabled to sense the function of the engineered tissue and provide stimulation for pacing, an electroactive polymer on the electronics enables it to release multiple drugs in parallel. It is envisioned that the integration of microelectronic devices into engineered tissues will provide a better way to monitor patient health from afar, as well as provide facile, more exact methods to control the healing process.
Identifiants
pubmed: 30838769
doi: 10.1002/smll.201805526
pmc: PMC7100044
mid: EMS86070
doi:
Substances chimiques
Biocompatible Materials
0
Delayed-Action Preparations
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1805526Subventions
Organisme : European Research Council
ID : 637943
Pays : International
Informations de copyright
© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Références
Adv Mater. 2019 Jan;31(1):e1803895
pubmed: 30406960
Nanoscale. 2014 Aug 21;6(16):9410-4
pubmed: 24744098
Anal Chim Acta. 2006 May 24;568(1-2):119-25
pubmed: 17761251
Allergy. 1997 Aug;52(8):877
pubmed: 9284994
Biomaterials. 2011 Feb;32(5):1280-90
pubmed: 21035179
Anaesth Intensive Care. 2002 Jun;30(3):370-1
pubmed: 12075649
Adv Mater. 2013 Aug 27;25(32):4459-65
pubmed: 23765688
Nat Protoc. 2006;1(4):1711-24
pubmed: 17487154
Nat Commun. 2014 Feb 25;5:3329
pubmed: 24569383
Ann Intern Med. 2009 Mar 17;150(6):396-404
pubmed: 19293072
Proc Natl Acad Sci U S A. 2009 Sep 1;106(35):14990-5
pubmed: 19706385
Curr Opin Biotechnol. 2017 Oct;47:23-29
pubmed: 28578251
J Control Release. 2006 Feb 21;110(3):531-41
pubmed: 16360955
Heart Rhythm. 2009 Jun;6(6):848-56
pubmed: 19467515
Ann Thorac Surg. 2008 May;85(5):1704-11
pubmed: 18442570
Biofabrication. 2014 Jun;6(2):024101
pubmed: 24464690
Nano Lett. 2015 Oct 14;15(10):6979-84
pubmed: 26317328
Am J Physiol Heart Circ Physiol. 2008 Sep;295(3):H1243-H1252
pubmed: 18641274
Exp Cell Res. 2014 Feb 15;321(2):297-306
pubmed: 24240126
Nano Lett. 2017 Sep 13;17(9):5836-5842
pubmed: 28787578
Am J Physiol Heart Circ Physiol. 2004 Jul;287(1):H243-50
pubmed: 15016625
Nat Med. 2006 Apr;12(4):452-8
pubmed: 16582915
Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):1927-32
pubmed: 24449853
Tissue Eng Part B Rev. 2010 Apr;16(2):169-87
pubmed: 19698068
Science. 2011 Aug 12;333(6044):838-43
pubmed: 21836009
Nat Mater. 2012 Nov;11(11):986-94
pubmed: 22922448
Chem Biol Interact. 2008 Nov 25;176(2-3):227-33
pubmed: 18786522
Science. 2010 Mar 26;327(5973):1603-7
pubmed: 20339064
J Physiol. 1982 Jun;327:79-94
pubmed: 7120151
Am J Physiol. 1999 Aug;277(2):H433-44
pubmed: 10444466
Appl Phys Lett. 2009 Sep 28;95(13):133701
pubmed: 20145699
Nat Nanotechnol. 2016 Sep;11(9):776-82
pubmed: 27347837
Nat Mater. 2015 Dec;14(12):1286-92
pubmed: 26436341
Nat Nanotechnol. 2011 Sep 25;6(11):720-5
pubmed: 21946708
Nanotechnology. 2015 Jul 24;26(29):291002
pubmed: 26133998
Stem Cells Transl Med. 2015 Nov;4(11):1324-32
pubmed: 26371342
Biomaterials. 2013 Nov;34(34):8599-606
pubmed: 23953840
Eur Heart J. 2006 Jul;27(13):1610-9
pubmed: 16495286
N Engl J Med. 1987 Feb 19;316(8):455-66
pubmed: 3543680
J Mater Chem B. 2013 Oct 21;1(39):5210-5217
pubmed: 32263327
Regen Med. 2017 Apr;12(3):275-284
pubmed: 28498093
Circ Res. 2002 Feb 8;90(2):223-30
pubmed: 11834716
Heart Fail Rev. 2013 May;18(3):355-60
pubmed: 22661042
Biomaterials. 2010 Jan;31(2):226-41
pubmed: 19800684
Nat Mater. 2008 Dec;7(12):1003-10
pubmed: 18978786
Nat Mater. 2016 Jun;15(6):679-85
pubmed: 26974408
Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):5894-5899
pubmed: 28533392
J Control Release. 2018 Jul 10;281:189-195
pubmed: 29782947
Adv Healthc Mater. 2014 Jan;3(1):59-68
pubmed: 23868871
Biotechnol Bioeng. 2014 Jun;111(6):1246-57
pubmed: 24420414
Nat Nanotechnol. 2011 Jan;6(1):13-22
pubmed: 21151110
Nat Biotechnol. 2005 Oct;23(10):1294-301
pubmed: 16170313
Adv Mater. 2018 Aug;30(31):e1800572
pubmed: 29882230
Circulation. 2017 Mar 7;135(10):e146-e603
pubmed: 28122885
Nano Lett. 2016 May 11;16(5):2916-20
pubmed: 26674672
Nat Methods. 2016 Oct;13(10):875-82
pubmed: 27571550
Nat Nanotechnol. 2015 Jul;10(7):629-636
pubmed: 26053995
Nano Lett. 2014 Oct 8;14(10):5792-6
pubmed: 25176294
J Biomed Mater Res B Appl Biomater. 2005 Jan 15;72(1):156-65
pubmed: 15389493