Calcium sulfate bone cements with nanoscaled silk fibroin as inducer.
bone repair material
silk fibroin
silk nanofiber
α-calcium sulfate hemihydrate
Journal
Journal of biomedical materials research. Part B, Applied biomaterials
ISSN: 1552-4981
Titre abrégé: J Biomed Mater Res B Appl Biomater
Pays: United States
ID NLM: 101234238
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
06
12
2018
revised:
31
01
2019
accepted:
18
02
2019
pubmed:
7
3
2019
medline:
4
9
2020
entrez:
7
3
2019
Statut:
ppublish
Résumé
Both nanostructures and conformations of different protein/polysaccharide additives have critical influence on the performance of calcium sulfate (CS) bone cements. Silk fibroin (SF) as matrix and additives has been introduced to develop bone scaffolds and cements. Here, β-sheet-rich SF nanofibers (SFF) was used to tune the solidification of CS, achieving better mechanical and biological properties. The ratio of SFF was adjusted to further optimize CS functions. Compared to that regulated with natural silk fibers (NSF) and SF solutions (SFS), the SFF-induced CS showed smaller size and more filament structures. Better mechanical properties were achieved, suggesting the superiority of the SFF as the solidifying solution to combine with α-calcium sulfate hemihydrate (α-CSH) at the same liquid/solid (L/S) ratio. Scanning electron microscope, X-ray diffraction, Fourier transform infrared spectroscopy, setting time, porosity, mechanical performance test, degradation performance test, and water resistance test were used to demonstrate the properties of this bone repair cement. Cell culture experiments in vitro was used to evaluate the biocompatibility of this composited material. In conclusion, the results demonstrated that nanofibers was a better form of SF in the modification of CSH cement. And the research conducted in this article on improving the mechanical and biological properties of CSH would supported the reference for later clinical experiments. © 2019 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 107B:2611-2619, 2019.
Substances chimiques
Bone Cements
0
Fibroins
9007-76-5
Calcium Sulfate
WAT0DDB505
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2611-2619Subventions
Organisme : International Cooperation Project Foundation of Shanxi Province, China
ID : 201803D421076
Pays : International
Organisme : International Cooperation Project Foundation of Shanxi Province, China
ID : 201803D421060
Pays : International
Organisme : National Natural Science Foundation of China (NSFC)
ID : 51502192
Pays : International
Organisme : National Natural Science Foundation of China (NSFC)
ID : 31700689, 11502157, 11872263
Pays : International
Organisme : Scientific and Technological Innovation Programs of Higher Education Institutions in Shanxi (STIP)
ID : 2016142
Pays : International
Organisme : Natural Science Foundation for Young Scientists of Shanxi Province
ID : 2014021039-6
Pays : International
Organisme : Natural Science Foundation for Young Scientists of Shanxi Province
ID : 201801D221439
Pays : International
Informations de copyright
© 2019 Wiley Periodicals, Inc.
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