A reduction in sedentary behaviour in obese women during pregnancy reduces neonatal adiposity: the DALI randomised controlled trial.

Adiposity / physiology Animals Animals, Newborn Diabetes, Gestational / metabolism Exercise / physiology Female Humans Life Style Obesity / metabolism Pregnancy Randomized Controlled Trials as Topic Regression Analysis Sedentary Behavior
Lifestyle intervention Mediation Neonatal adiposity Randomised controlled trial

Journal

Diabetologia
ISSN: 1432-0428
Titre abrégé: Diabetologia
Pays: Germany
ID NLM: 0006777

Informations de publication

Date de publication:
06 2019
Historique:
received: 30 10 2018
accepted: 06 02 2019
pubmed: 7 3 2019
medline: 14 1 2020
entrez: 7 3 2019
Statut: ppublish

Résumé

Offspring of obese women are at increased risk of features of the metabolic syndrome, including obesity and diabetes. Lifestyle intervention in pregnancy might reduce adverse effects of maternal obesity on neonatal adiposity. In the Vitamin D And Lifestyle Intervention for Gestational Diabetes Mellitus (GDM) Prevention (DALI) lifestyle trial, 436 women with a BMI ≥29 kg/m Outcomes were available from 334 neonates. A reduction in sum of skinfolds (-1.8 mm; 95% CI -3.5, -0.2; p = 0.03), fat mass (-63 g; 95% CI -124, -2; p = 0.04), fat percentage (-1.2%; 95% CI -2.4%, -0.04%; p = 0.04) and leptin (-3.80 μg/l; 95% CI -7.15, -0.45; p = 0.03) was found in the HE&PA group, and reduced leptin in female neonates in the PA group (-5.79 μg/l; 95% CI -11.43, -0.14; p = 0.05) compared with UC. Reduced sedentary time, but not gestational weight gain, mediated intervention effects on leptin in both the HE&PA and PA groups. The HE&PA intervention resulted in reduced adiposity in neonates. Reduced sedentary time seemed to drive the intervention effect on cord blood leptin. Implications for future adiposity and diabetes risk of the offspring need to be elucidated. ISRCTN70595832.

Identifiants

DOI: 10.1007/s00125-019-4842-0 PMID: 30840112 PMC: PMC6509072
pubmed: 30840112
doi: 10.1007/s00125-019-4842-0
pii: 10.1007/s00125-019-4842-0
pmc: PMC6509072
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

915-925

Références

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Auteurs

Mireille N M van Poppel (MNM)

Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands. Mireille.van-poppel@uni-graz.at.
Institute of Sport Science, University of Graz, Mozartgasse 14, 8010, Graz, Austria. Mireille.van-poppel@uni-graz.at.
ORCID: 0000-0001-5694-4324

David Simmons (D)

Macarthur Clinical School, Western Sydney University, Sydney, NSW, Australia.
Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK.

Roland Devlieger (R)

Department of Development and Regeneration: Pregnancy, Fetus and Neonate, KU Leuven, Leuven, Belgium.
Department of Gynaecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium.

F Andre van Assche (FA)

Department of Development and Regeneration: Pregnancy, Fetus and Neonate, KU Leuven, Leuven, Belgium.
Department of Gynaecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium.

Goele Jans (G)

Department of Development and Regeneration: Pregnancy, Fetus and Neonate, KU Leuven, Leuven, Belgium.
Department of Gynaecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium.

Sander Galjaard (S)

Department of Development and Regeneration: Pregnancy, Fetus and Neonate, KU Leuven, Leuven, Belgium.
Department of Gynaecology and Obstetrics, University Hospitals Leuven, Leuven, Belgium.
Division of Obstetrics and Prenatal Medicine, Department of Obstetrics and Gynaecology, Erasmus University Medical Center, Rotterdam, the Netherlands.

Rosa Corcoy (R)

Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
Centro de Investigación Biomédica en Red (CIBER) Bioengineering, Biomaterials and Nanotechnology, Instituto de Salud Carlos III (ISCIII), Madrid, Spain.

Juan M Adelantado (JM)

Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.

Fidelma Dunne (F)

Galway Diabetes Research Centre, National University of Ireland, Galway, Ireland.
College of Medicine, Nursing and Health Sciences, National University of Ireland, Galway, Ireland.

Jürgen Harreiter (J)

Gender Medicine Unit, Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

Alexandra Kautzky-Willer (A)

Gender Medicine Unit, Endocrinology and Metabolism, Department of Internal Medicine III, Medical University of Vienna, Vienna, Austria.

Peter Damm (P)

Center for Pregnant Women with Diabetes, Departments of Endocrinology and Obstetrics, Rigshospitalet, Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Elisabeth R Mathiesen (ER)

Center for Pregnant Women with Diabetes, Departments of Endocrinology and Obstetrics, Rigshospitalet, Institute of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Dorte M Jensen (DM)

Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.
Department of Gynaecology and Obstetrics, Odense University Hospital, Odense, Denmark.
Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.

Lise-Lotte Andersen (LL)

Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.
Department of Gynaecology and Obstetrics, Odense University Hospital, Odense, Denmark.
Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.

Mette Tanvig (M)

Steno Diabetes Center Odense, Odense University Hospital, Odense, Denmark.
Department of Gynaecology and Obstetrics, Odense University Hospital, Odense, Denmark.
Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark.
, Region of Southern Denmark, Denmark.

Annunziata Lapolla (A)

Dipartimento di Medicina, Università Degli Studi di Padova, Padua, Italy.

Maria G Dalfra (MG)

Dipartimento di Medicina, Università Degli Studi di Padova, Padua, Italy.

Alessandra Bertolotto (A)

Department of Clinical and Experimental Medicine, Azienda Ospedaliero Universitaria Pisana, Pisa, Italy.

Ewa Wender-Ozegowska (E)

Medical Faculty I, Poznań University of Medical Sciences, Poznań, Poland.

Agnieszka Zawiejska (A)

Medical Faculty I, Poznań University of Medical Sciences, Poznań, Poland.

David Hill (D)

Recherche en Santé Lawson SA, Bronschhofen, Switzerland.

Frank J Snoek (FJ)

Department of Medical Psychology, Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Judith G M Jelsma (JGM)

Department of Public and Occupational Health, Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.

Gernot Desoye (G)

Department of Obstetrics and Gynaecology, Medical University of Graz, Graz, Austria.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques › Constitution physique › Composition corporelle › Répartition du tissu adipeux › Adiposité › A reduction in sedentary behaviour in obese...
questionsmedicales.fr › Eucaryotes › Animaux › A reduction in sedentary behaviour in obese...
questionsmedicales.fr › Eucaryotes › Animaux › Groupes animaux › Animaux nouveau-nés › A reduction in sedentary behaviour in obese...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Diabète gestationnel › A reduction in sedentary behaviour in obese...
questionsmedicales.fr › Activités humaines › Exercice physique › A reduction in sedentary behaviour in obese...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A reduction in sedentary behaviour in obese...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Mode de vie › A reduction in sedentary behaviour in obese...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › A reduction in sedentary behaviour in obese...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › A reduction in sedentary behaviour in obese...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études cliniques comme sujet › Essais cliniques comme sujet › Essais cliniques contrôlés comme sujet › Essais contrôlés randomisés comme sujet › A reduction in sedentary behaviour in obese...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de régression › A reduction in sedentary behaviour in obese...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Mode de vie › Mode de vie sédentaire › A reduction in sedentary behaviour in obese...