Transmission phenotype of Mycobacterium tuberculosis strains is mechanistically linked to induction of distinct pulmonary pathology.
Journal
PLoS pathogens
ISSN: 1553-7374
Titre abrégé: PLoS Pathog
Pays: United States
ID NLM: 101238921
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
18
06
2018
accepted:
02
02
2019
revised:
18
03
2019
pubmed:
7
3
2019
medline:
12
4
2019
entrez:
7
3
2019
Statut:
epublish
Résumé
In a study of household contacts (HHC), households were categorized into High (HT) and Low (LT) transmission groups based on the proportion of HHC with a positive tuberculin skin test. The Mycobacterium tuberculosis (Mtb) strains from HT and LT index cases of the households were designated Mtb-HT and Mtb-LT, respectively. We found that C3HeB/FeJ mice infected with Mtb-LT strains exhibited significantly higher bacterial burden compared to Mtb-HT strains and also developed diffused inflammatory lung pathology. In stark contrast, a significant number of mice infected with Mtb-HT strains developed caseating granulomas, a lesion type with high potential to cavitate. None of the Mtb-HT infected animals developed diffused inflammatory lung pathology. A link was observed between increased in vitro replication of Mtb-LT strains and their ability to induce significantly high lipid droplet formation in macrophages. These results support that distinct early interactions of Mtb-HT and Mtb-LT strains with macrophages and subsequent differential trajectories in pathological disease may be the mechanism underlying their transmission potential.
Identifiants
pubmed: 30840702
doi: 10.1371/journal.ppat.1007613
pii: PPATHOGENS-D-18-01245
pmc: PMC6422314
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1007613Subventions
Organisme : NIAID NIH HHS
ID : U19 AI111276
Pays : United States
Organisme : NIAID NIH HHS
ID : U01 AI065663
Pays : United States
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
J Immunol. 1999 Jun 1;162(11):6740-6
pubmed: 10352293
Epidemiol Infect. 1999 Dec;123(3):445-50
pubmed: 10694155
Arch Intern Med. 2000 Mar 13;160(5):630-6
pubmed: 10724048
Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8560-5
pubmed: 10890913
Genome Res. 2001 Apr;11(4):547-54
pubmed: 11282970
Arch Intern Med. 2001 Oct 8;161(18):2254-8
pubmed: 11575983
Emerg Infect Dis. 2001 Sep-Oct;7(5):880-3
pubmed: 11747703
Bull Int Union Tuberc. 1975;50(1):107-21
pubmed: 1218286
Microbiology. 2002 Oct;148(Pt 10):2951-8
pubmed: 12368428
Clin Exp Immunol. 2003 Jul;133(1):30-7
pubmed: 12823275
Clin Infect Dis. 2003 Sep 1;37(5):665-72
pubmed: 12942398
Am Rev Respir Dis. 1960 Sep;82:358-69
pubmed: 13835667
Am Rev Respir Dis. 1962 Apr;85:511-25
pubmed: 14492300
Emerg Infect Dis. 2003 Dec;9(12):1553-7
pubmed: 14720395
J Immunol. 2004 Mar 1;172(5):2748-51
pubmed: 14978073
Tuberculosis (Edinb). 2004;84(5):337-40
pubmed: 15207809
Nature. 2004 Sep 2;431(7004):84-7
pubmed: 15343336
J Infect Dis. 2005 Feb 1;191(3):453-60
pubmed: 15633105
Nature. 2005 Apr 7;434(7034):767-72
pubmed: 15815631
J Clin Microbiol. 2005 Nov;43(11):5779-81
pubmed: 16272518
Tuberculosis (Edinb). 2006 Sep;86(5):357-62
pubmed: 16360339
Emerg Infect Dis. 2006 May;12(5):736-43
pubmed: 16704829
Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15594-8
pubmed: 17028173
J Clin Microbiol. 2007 May;45(5):1483-90
pubmed: 17360841
Clin Infect Dis. 2007 May 15;44(10):1349-57
pubmed: 17443474
Trans R Soc Trop Med Hyg. 2008 Oct;102(10):955-65
pubmed: 18513773
J Infect Dis. 2008 Oct 1;198(7):1037-43
pubmed: 18702608
Clin Infect Dis. 2008 Nov 15;47(10):1252-9
pubmed: 18834315
PLoS Pathog. 2008 Nov;4(11):e1000204
pubmed: 19002241
J Clin Microbiol. 2009 May;47(5):1338-43
pubmed: 19261801
Am J Pathol. 2009 Jun;174(6):2190-201
pubmed: 19443700
Tuberculosis (Edinb). 2009 Jul;89(4):252-5
pubmed: 19541541
Nat Immunol. 2009 Sep;10(9):943-8
pubmed: 19692995
PLoS One. 2010 Jul 23;5(7):e11765
pubmed: 20668705
Tuberculosis (Edinb). 2010 Sep;90(5):319-25
pubmed: 20832364
Tuberculosis (Edinb). 2011 May;91(3):244-9
pubmed: 21367661
PLoS Pathog. 2011 Mar;7(3):e1001307
pubmed: 21408618
Tuberculosis (Edinb). 2011 Jul;91(4):329-38
pubmed: 21478054
J Clin Invest. 2011 May;121(5):1827-33
pubmed: 21519144
PLoS Pathog. 2011 Jun;7(6):e1002093
pubmed: 21731490
PLoS One. 2011;6(9):e25075
pubmed: 21949856
J Infect Dis. 2012 Feb 15;205(4):595-602
pubmed: 22198962
Genetics. 2012 Feb;190(2):437-47
pubmed: 22345611
Am J Respir Crit Care Med. 2012 Sep 1;186(5):450-7
pubmed: 22798319
Clin Infect Dis. 2012 Nov;55(9):1179-87
pubmed: 22865872
Mamm Genome. 2012 Oct;23(9-10):713-8
pubmed: 22892839
PLoS One. 2012;7(8):e42323
pubmed: 22912700
PLoS One. 2012;7(8):e43170
pubmed: 22916219
Cell Host Microbe. 2012 Nov 15;12(5):669-81
pubmed: 23159056
Am J Respir Crit Care Med. 2013 May 1;187(9):1007-15
pubmed: 23306539
Curr Atheroscler Rep. 2013 May;15(5):325
pubmed: 23526298
Emerg Infect Dis. 2013 May;19(5):701-11
pubmed: 23648234
PLoS One. 2013 Jun 26;8(6):e67277
pubmed: 23840651
Infect Immun. 2013 Oct;81(10):3750-6
pubmed: 23897611
MBio. 2013 Jul 30;4(4):null
pubmed: 23900170
BMC Infect Dis. 2013 Oct 17;13:484
pubmed: 24134504
Immunity. 2014 Jan 16;40(1):128-39
pubmed: 24412617
PLoS One. 2014 Jul 02;9(7):e100984
pubmed: 24988000
PLoS Pathog. 2014 Jul 24;10(7):e1004265
pubmed: 25058590
Semin Immunol. 2014 Dec;26(6):431-44
pubmed: 25453224
Cell Microbiol. 2015 Sep;17(9):1332-49
pubmed: 25772333
Dis Model Mech. 2015 Jun;8(6):591-602
pubmed: 26035867
Dis Model Mech. 2015 Sep;8(9):1141-53
pubmed: 26204894
Semin Immunopathol. 2016 Mar;38(2):221-37
pubmed: 26542392
Colorectal Dis. 2016 Dec;18(12):1172-1178
pubmed: 27232282
Dis Model Mech. 2016 Jul 1;9(7):779-88
pubmed: 27482816
MBio. 2016 Sep 20;7(5):
pubmed: 27651361
Front Cell Infect Microbiol. 2016 Oct 07;6:122
pubmed: 27774438
Am J Respir Crit Care Med. 2017 Jun 1;195(11):1519-1527
pubmed: 27997216
Tuberculosis (Edinb). 2017 May;104:79-86
pubmed: 28454653
Eur Respir J. 2018 Jan 18;51(1):
pubmed: 29348181
PLoS Pathog. 2018 Jan 25;14(1):e1006874
pubmed: 29370315
Tuberculosis (Edinb). 2018 Mar;109:123-133
pubmed: 29559116
Am Rev Respir Dis. 1973 Oct;108(4):799-804
pubmed: 4741874
Am J Epidemiol. 1995 Jul 1;142(1):3-14
pubmed: 7785671
N Engl J Med. 1998 Mar 5;338(10):633-9
pubmed: 9486991