Quantification of Immunoglobulin G against Trypanosoma cruzi in Individuals with Chronic Chagas Disease Treated with Nifurtimox and Evaluated in Prolonged Follow-Up.
Antibodies, Protozoan
/ blood
Chagas Disease
/ drug therapy
Chronic Disease
Enzyme-Linked Immunosorbent Assay
Female
Fluorescent Antibody Technique, Indirect
Follow-Up Studies
Humans
Immunoglobulin G
/ blood
Male
Middle Aged
Nifurtimox
/ administration & dosage
Treatment Outcome
Trypanocidal Agents
/ administration & dosage
Trypanosoma cruzi
/ immunology
ELISA
IFA
IgG
chronic Chagas disease
follow-up
nifurtimox
Journal
The Korean journal of parasitology
ISSN: 1738-0006
Titre abrégé: Korean J Parasitol
Pays: Korea (South)
ID NLM: 9435800
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
23
10
2018
accepted:
22
01
2019
entrez:
7
3
2019
pubmed:
7
3
2019
medline:
13
4
2019
Statut:
ppublish
Résumé
In the indeterminate chronic period of Chagas disease (ChD) the treatment has not been conclusive, because the serological negativization requires many years. This study aims to evaluate the efficacy of nifurtimox (NF) in the treatment of chronic ChD in prolonged follow-up by serological techniques of indirect immunofluorescence assay (IFA) and enzyme-linked immunosorbent assay (ELISA) IgG comparing 2 groups of patients, treated and non treated. Mann-Whitney test was performed for ELISA and IFA, with significant difference between the groups (P < 0.05). IgG levels were lower in individuals treated compared with untreated patients, indicating chemotherapeutic efficacy in prolonged follow-up.
Identifiants
pubmed: 30840798
pii: kjp.2019.57.1.39
doi: 10.3347/kjp.2019.57.1.39
pmc: PMC6409214
doi:
Substances chimiques
Antibodies, Protozoan
0
Immunoglobulin G
0
Trypanocidal Agents
0
Nifurtimox
M84I3K7C2O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
39-41Subventions
Organisme : Fondecyt Projects
ID : 1080445
Organisme : Fondecyt Projects
ID : 1161485
Références
Am J Trop Med Hyg. 2007 Jan;76(1):58-61
pubmed: 17255230
Rev Med Chil. 2008 Mar;136(3):385-93
pubmed: 18575667
Enferm Infecc Microbiol Clin. 2010 May;28(5):284-93
pubmed: 19962790
N Engl J Med. 2011 Jun 30;364(26):2527-34
pubmed: 21714649
Rev Med Chil. 2011 Feb;139(2):247-57
pubmed: 21773664
Rev Med Chil. 2011 Feb;139(2):258-66
pubmed: 21773665
Infect Dis Clin North Am. 2012 Jun;26(2):275-91
pubmed: 22632639
Wkly Epidemiol Rec. 2015 Feb 6;90(6):33-43
pubmed: 25671846
PLoS One. 2015 Oct 05;10(10):e0139363
pubmed: 26436678
Lancet. 2018 Jan 6;391(10115):82-94
pubmed: 28673423