Microbiota Depletion Impairs Thermogenesis of Brown Adipose Tissue and Browning of White Adipose Tissue.
IL-4
UCP1
antibiotics
beige adipocytes
brite adipocytes
brown adipose tissue
butyrate
germ free mice
gut microbiota
hermogenesis
macrophage
white adipose tissue
Journal
Cell reports
ISSN: 2211-1247
Titre abrégé: Cell Rep
Pays: United States
ID NLM: 101573691
Informations de publication
Date de publication:
05 03 2019
05 03 2019
Historique:
received:
02
11
2018
revised:
09
01
2019
accepted:
02
02
2019
entrez:
7
3
2019
pubmed:
7
3
2019
medline:
6
6
2020
Statut:
ppublish
Résumé
The relation between gut microbiota and the host has been suggested to benefit metabolic homeostasis. Brown adipose tissue (BAT) and beige adipocytes facilitate thermogenesis to maintain host core body temperature during cold exposure. However, the potential impact of gut microbiota on the thermogenic process is confused. Here, we evaluated how BAT and white adipose tissue (WAT) responded to temperature challenges in mice lacking gut microbiota. We found that microbiota depletion via treatment with different cocktails of antibiotics (ABX) or in germ-free (GF) mice impaired the thermogenic capacity of BAT by blunting the increase in the expression of uncoupling protein 1 (UCP1) and reducing the browning process of WAT. Gavage of the bacterial metabolite butyrate increased the thermogenic capacity of ABX-treated mice, reversing the deficit. Our results indicate that gut microbiota contributes to upregulated thermogenesis in the cold environment and that this may be partially mediated via butyrate.
Identifiants
pubmed: 30840893
pii: S2211-1247(19)30177-9
doi: 10.1016/j.celrep.2019.02.015
pii:
doi:
Substances chimiques
Uncoupling Protein 1
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2720-2737.e5Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.