Thermochemoradiotherapy Using Superselective Intra-arterial Infusion for Patients With Oral Cancer With Cervical Lymph Node Metastases.
Adult
Aged
Aged, 80 and over
Antineoplastic Agents
/ administration & dosage
Carcinoma, Squamous Cell
/ diagnostic imaging
Chemoradiotherapy
/ adverse effects
Combined Modality Therapy
Docetaxel
/ administration & dosage
Female
Humans
Hyperthermia, Induced
/ adverse effects
Infusions, Intra-Arterial
Lymph Nodes
/ pathology
Lymphatic Metastasis
Male
Middle Aged
Mouth Neoplasms
/ diagnostic imaging
Neck
Neoplasm Staging
Oral squamous cell carcinoma
cervical lymph node metastasis
concurrent radiotherapy
hyperthermia
retrograde superselective intra-arterial chemotherapy
Journal
Anticancer research
ISSN: 1791-7530
Titre abrégé: Anticancer Res
Pays: Greece
ID NLM: 8102988
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
21
01
2019
revised:
11
02
2019
accepted:
14
02
2019
entrez:
8
3
2019
pubmed:
8
3
2019
medline:
12
3
2019
Statut:
ppublish
Résumé
We aimed to retrospectively investigate the outcomes and pathological effects of retrograde superselective intra-arterial chemoradiotherapy (IACRT) combined with hyperthermia on metastatic lymph nodes of patients with oral squamous cell carcinoma. Patients with lymph node metastasis from oral cancer were treated with IACRT using cisplatin plus docetaxel combined with hyperthermia prior to surgical removal 8 weeks after completion of IACRT and hyperthermia. The locoregional control and overall survival rates were calculated using the Kaplan-Meier method. A total of 35 patients received the combination therapy of whom 26 received it as definitive treatment and in the rest, it was administered as preoperative treatment. The 5-year locoregional control and overall survivaI rates were 95.6% and 80.2% in the definitive-treatment group, and 100% and 66.6% in the preoperative-treatment group, respectively. The combination therapy provided good outcomes in patients with lymph node metastases from advanced oral cancer.
Identifiants
pubmed: 30842170
pii: 39/3/1365
doi: 10.21873/anticanres.13250
doi:
Substances chimiques
Antineoplastic Agents
0
Docetaxel
15H5577CQD
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
1365-1373Informations de copyright
Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.