SUMO1 Modification Facilitates Avibirnavirus Replication by Stabilizing Polymerase VP1.
Avibirnavirus
/ metabolism
HEK293 Cells
Host-Pathogen Interactions
Humans
Infectious bursal disease virus
/ metabolism
Protein Processing, Post-Translational
RNA-Dependent RNA Polymerase
/ genetics
SUMO-1 Protein
/ metabolism
Sumoylation
Ubiquitination
Viral Proteins
/ metabolism
Viral Structural Proteins
/ genetics
Virus Replication
/ physiology
SUMO1 modification
VP1 protein
avibirnavirus
stability
viral replication
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
15 05 2019
15 05 2019
Historique:
received:
12
12
2018
accepted:
23
02
2019
pubmed:
8
3
2019
medline:
3
3
2020
entrez:
8
3
2019
Statut:
epublish
Résumé
SUMOylation is a posttranslational modification that has crucial roles in diverse cellular biological pathways and in various viral life cycles. In this study, we found that the VP1 protein, the RNA-dependent RNA polymerase of avibirnavirus infectious bursal disease virus (IBDV), regulates virus replication by SUMOylation during infection. Our data demonstrated that the polymerase VP1 is efficiently modified by small ubiquitin-like modifier 1 (SUMO1) in avibirnavirus-infected cell lines. Mutation analysis showed that residues
Identifiants
pubmed: 30842328
pii: JVI.02227-18
doi: 10.1128/JVI.02227-18
pmc: PMC6498067
pii:
doi:
Substances chimiques
SUMO-1 Protein
0
SUMO1 protein, human
0
VP1 protein, infectious bursal disease virus
0
Viral Proteins
0
Viral Structural Proteins
0
RNA-Dependent RNA Polymerase
EC 2.7.7.48
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2019 American Society for Microbiology.
Références
J Virol. 2019 Jan 17;93(3):
pubmed: 30429342
Nat Rev Microbiol. 2013 Jun;11(6):400-11
pubmed: 23624814
PLoS One. 2015 Jun 05;10(6):e0128828
pubmed: 26046798
J Virol. 2013 Apr;87(8):4704-15
pubmed: 23365455
Nat Rev Mol Cell Biol. 2015 May;16(5):322-4
pubmed: 25907614
J Gen Virol. 1995 Feb;76 ( Pt 2):437-43
pubmed: 7844565
Virus Res. 2011 Jun;158(1-2):12-27
pubmed: 21376763
Immunity. 2016 Sep 20;45(3):555-569
pubmed: 27637147
J Virol. 2014 Oct;88(19):11154-65
pubmed: 25031338
Autophagy. 2015;11(3):503-15
pubmed: 25714412
Nat Rev Mol Cell Biol. 2010 Dec;11(12):861-71
pubmed: 21102611
Nat Commun. 2013;4:1850
pubmed: 23673635
Oncogene. 2014 Aug 21;33(34):4316-29
pubmed: 24362530
Nat Commun. 2012 Jun 19;3:911
pubmed: 22713753
PLoS Pathog. 2015 Mar 12;11(3):e1004726
pubmed: 25763818
J Virol. 2001 Nov;75(22):10815-28
pubmed: 11602723
Mol Immunol. 2009 Jun;46(10):1964-9
pubmed: 19361862
Mol Cell. 2006 Nov 3;24(3):341-54
pubmed: 17081986
J Gen Virol. 2004 Aug;85(Pt 8):2221-2229
pubmed: 15269362
J Virol. 2016 Nov 14;90(23):10472-10485
pubmed: 27630238
J Mol Cell Biol. 2011 Oct;3(5):283-92
pubmed: 22028379
Nat Commun. 2015 Nov 19;6:8899
pubmed: 26582366
DNA Cell Biol. 2006 Nov;25(11):646-53
pubmed: 17132096
J Virol. 2015 Nov;89(21):11165-8
pubmed: 26311889
Nat Rev Mol Cell Biol. 2012 Dec;13(12):755-66
pubmed: 23175280
J Biol Chem. 2006 Jun 9;281(23):16117-27
pubmed: 16524884
Nat Struct Mol Biol. 2014 Oct;21(10):927-36
pubmed: 25218447
Nat Commun. 2014 Jun 23;5:4234
pubmed: 24953629
J Virol. 2010 Jan;84(2):918-27
pubmed: 19889771
Mol Cell Proteomics. 2008 Mar;7(3):612-25
pubmed: 18056921
Nat Commun. 2015 Nov 24;6:8917
pubmed: 26596471
J Virol. 2016 Apr 14;90(9):4308-4319
pubmed: 26889037
J Virol. 2005 Oct;79(19):12253-63
pubmed: 16160151
J Virol. 2005 Jan;79(2):910-7
pubmed: 15613319
Proc Natl Acad Sci U S A. 2007 May 1;104(18):7385-90
pubmed: 17456597
J Virol. 2002 Mar;76(5):2393-402
pubmed: 11836417
Nat Commun. 2017 Jun 01;8:15426
pubmed: 28569748
J Virol. 2015 Mar;89(5):2777-91
pubmed: 25540360
Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20540-5
pubmed: 18077388
Nat Struct Mol Biol. 2013 Apr;20(4):525-31
pubmed: 23503365
J Virol. 2014 Aug;88(16):9379-90
pubmed: 24920808
Virology. 2009 Dec 5;395(1):87-96
pubmed: 19801157