[Successful management of drug-induced skin rash in a relapsed multiple myeloma patient with pomalidomide desensitization].


Journal

[Rinsho ketsueki] The Japanese journal of clinical hematology
ISSN: 0485-1439
Titre abrégé: Rinsho Ketsueki
Pays: Japan
ID NLM: 2984782R

Informations de publication

Date de publication:
Historique:
entrez: 8 3 2019
pubmed: 8 3 2019
medline: 15 8 2019
Statut: ppublish

Résumé

A 71-year-old man diagnosed with IgG-κ type multiple myeloma 11 years ago was treated with low doses of pomalidomide (POM, 1 mg/daily) and dexamethasone (20 mg/week) as the third-line of salvage regimen. The treatment was terminated 4 days later owing to the appearance of a severe skin rash, which had also occurred after previous treatment with lenalidomide. After 2 months, POM was readministered via an outpatient desensitization protocol under prednisolone administration. During five cycles of POM-treatment, no severe skin rash appeared, and partial remission was obtained even though the final POM dose was as low as 1 mg/day.

Identifiants

pubmed: 30842382
doi: 10.11406/rinketsu.60.137
doi:

Substances chimiques

Thalidomide 4Z8R6ORS6L
Dexamethasone 7S5I7G3JQL
pomalidomide D2UX06XLB5

Types de publication

Case Reports Journal Article

Langues

jpn

Pagination

137-139

Auteurs

Masao Hagihara (M)

Department of Hematology, Eiju General Hospital.

Shiro Ide (S)

Department of Hematology, Eiju General Hospital.

Shin Ohara (S)

Department of Hematology, Eiju General Hospital.

Tomoyuki Uchida (T)

Department of Hematology, Eiju General Hospital.

Morihiro Inoue (M)

Department of Hematology, Eiju General Hospital.

Jian Hua (J)

Department of Hematology, Eiju General Hospital.

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Classifications MeSH