[Successful management of drug-induced skin rash in a relapsed multiple myeloma patient with pomalidomide desensitization].
Desensitization
Myeloma
Pomalidomide
Skin rash
Journal
[Rinsho ketsueki] The Japanese journal of clinical hematology
ISSN: 0485-1439
Titre abrégé: Rinsho Ketsueki
Pays: Japan
ID NLM: 2984782R
Informations de publication
Date de publication:
Historique:
entrez:
8
3
2019
pubmed:
8
3
2019
medline:
15
8
2019
Statut:
ppublish
Résumé
A 71-year-old man diagnosed with IgG-κ type multiple myeloma 11 years ago was treated with low doses of pomalidomide (POM, 1 mg/daily) and dexamethasone (20 mg/week) as the third-line of salvage regimen. The treatment was terminated 4 days later owing to the appearance of a severe skin rash, which had also occurred after previous treatment with lenalidomide. After 2 months, POM was readministered via an outpatient desensitization protocol under prednisolone administration. During five cycles of POM-treatment, no severe skin rash appeared, and partial remission was obtained even though the final POM dose was as low as 1 mg/day.
Identifiants
pubmed: 30842382
doi: 10.11406/rinketsu.60.137
doi:
Substances chimiques
Thalidomide
4Z8R6ORS6L
Dexamethasone
7S5I7G3JQL
pomalidomide
D2UX06XLB5
Types de publication
Case Reports
Journal Article
Langues
jpn