Microheterogeneity of Topoisomerase IA/IB and Their DNA-Bound States.
Journal
ACS omega
ISSN: 2470-1343
Titre abrégé: ACS Omega
Pays: United States
ID NLM: 101691658
Informations de publication
Date de publication:
28 Feb 2019
28 Feb 2019
Historique:
received:
20
10
2018
accepted:
11
01
2019
entrez:
8
3
2019
pubmed:
8
3
2019
medline:
8
3
2019
Statut:
ppublish
Résumé
Topoisomerases are important complex enzymes that modulate DNA topology to maintain chromosome superstructure and integrity. These enzymes are involved in many cellular processes that resolve specific DNA superstructures and intermediates. The low abundance combined with the biological heterogeneity of relevant intermediates of topoisomerases makes their structural information not readily accessible using traditional structural biology tools (e.g., NMR and X-ray crystallography). In the present work, a second-generation trapped ion mobility spectrometry-mass spectrometry (TIMS-MS) was used to study
Identifiants
pubmed: 30842985
doi: 10.1021/acsomega.8b02887
pmc: PMC6396120
doi:
Types de publication
Journal Article
Langues
eng
Pagination
3619-3626Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM054226
Pays : United States
Organisme : NIAID NIH HHS
ID : R21 AI125973
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no competing financial interest.
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