Genome-wide meta-analysis identifies novel loci associated with free triiodothyronine and thyroid-stimulating hormone.
Free thyroxine
Free triiodothyronine
Genome-wide association studies
Meta-analysis
Thyroid-stimulating hormone
Journal
Journal of endocrinological investigation
ISSN: 1720-8386
Titre abrégé: J Endocrinol Invest
Pays: Italy
ID NLM: 7806594
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
received:
01
10
2018
accepted:
27
02
2019
pubmed:
8
3
2019
medline:
7
2
2020
entrez:
8
3
2019
Statut:
ppublish
Résumé
Thyroid hormones are essential for the normal function of almost all human tissues, and have critical roles in metabolism, differentiation and growth. Free triiodothyronine (fT3), free thyroxine (fT4) and thyroid-stimulating hormone (TSH) levels are under strong genetic influence; however, most of the heritability is yet unexplained. In order to identify novel loci associated with fT3, fT4 and TSH serum levels we performed a genome-wide meta-analysis of 7 411 206 polymorphisms in up to 1731 euthyroid individuals from three Croatian cohorts from Dalmatia region: two genetically isolated island populations and one mainland population. Additionally, we also performed a bivariate analysis of fT3 and fT4 levels. The EPHB2 gene variant rs67142165 reached genome-wide significance for association with fT3 plasma levels (P = 9.27 × 10 We identified a first genome-wide significant variant associated with fT3 plasma levels, as well as a novel locus associated with TSH plasma levels. These findings are biologically relevant and enrich our knowledge about the genetic basis of pituitary-thyroid axis function.
Identifiants
pubmed: 30843173
doi: 10.1007/s40618-019-01030-9
pii: 10.1007/s40618-019-01030-9
doi:
Substances chimiques
Triiodothyronine
06LU7C9H1V
Thyrotropin
9002-71-5
Types de publication
Journal Article
Meta-Analysis
Langues
eng
Sous-ensembles de citation
IM
Pagination
1171-1180Subventions
Organisme : Medical Research Council
ID : MC_UU_00007/10
Pays : United Kingdom
Organisme : Medical Research Council (UK), European Commission Framework 6 project EUROSPAN (Contract No.LSHG-CT-2006-018947), the Republic of Croatia Ministry of Science, Education and Sports research grant (216-1080315-0302), the Croatian Science Foundation (grant 8875), CEKOM (Ministry of Economy, Entrepreneurship and Crafts) and the Research Centre of Excellence in Personalized Medicine (Ministry of Science and Education)
ID : "10 001 Dalmatians" project
Organisme : Hrvatska Zaklada za Znanost
ID : 1498
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