Palladium-Catalyzed C8-H Acylation of 1-Naphthylamines with Acyl Chlorides.

Journal

Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393

Informations de publication

Date de publication:
15 03 2019
Historique:
pubmed: 8 3 2019
medline: 8 3 2019
entrez: 8 3 2019
Statut: ppublish

Résumé

A facile and efficient protocol for palladium-catalyzed regioselective C8-H acylation of 1-naphthylamine derivatives with acyl chlorides has been developed. The reaction exhibits broad functional group tolerance, and both aromatic and α,β-unsaturated acyl chlorides can be effectively coupled with 1-naphthylamines. Moreover, the picolinamide moiety as a bidentate directing likely plays a key role in this regioselective transformation.

Identifiants

DOI: 10.1021/acs.orglett.9b00283 PMID: 30843701
pubmed: 30843701
doi: 10.1021/acs.orglett.9b00283
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Pagination

1726-1729

Auteurs

Xiaomeng Yu (X)

The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities , Zhengzhou University , Zhengzhou 450052 , People's Republic of China.

Fan Yang (F)

The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities , Zhengzhou University , Zhengzhou 450052 , People's Republic of China.

Yusheng Wu (Y)

Tetranov Biopharm , LLC & Collaborative Innovation Center of New Drug Research and Safety Evaluation , Zhengzhou 450052 , People's Republic of China.
ORCID: 0000-0001-7023-9541

Yangjie Wu (Y)

The College of Chemistry and Molecular Engineering, Henan Key Laboratory of Chemical Biology and Organic Chemistry, Key Laboratory of Applied Chemistry of Henan Universities , Zhengzhou University , Zhengzhou 450052 , People's Republic of China.
ORCID: 0000-0002-0134-0870

Classifications MeSH