Hypoxia impacts human MSC response to substrate stiffness during chondrogenic differentiation.
Cartilage
Hypoxia
Mechanotransduction
Mesenchymal stem cell
Tissue engineering
Journal
Acta biomaterialia
ISSN: 1878-7568
Titre abrégé: Acta Biomater
Pays: England
ID NLM: 101233144
Informations de publication
Date de publication:
15 04 2019
15 04 2019
Historique:
received:
26
10
2018
revised:
27
02
2019
accepted:
03
03
2019
pubmed:
8
3
2019
medline:
22
4
2020
entrez:
8
3
2019
Statut:
ppublish
Résumé
Tissue engineering strategies often aim to direct tissue formation by mimicking conditions progenitor cells experience within native tissues. For example, to create cartilage in vitro, researchers often aim to replicate the biochemical and mechanical milieu cells experience during cartilage formation in the developing limb bud. This includes stimulating progenitors with TGF-β
Identifiants
pubmed: 30844569
pii: S1742-7061(19)30168-0
doi: 10.1016/j.actbio.2019.03.002
pmc: PMC6481516
pii:
doi:
Substances chimiques
Acrylic Resins
0
Hydrogels
0
TGFB1 protein, human
0
TGFB3 protein, human
0
Transforming Growth Factor beta1
0
Transforming Growth Factor beta3
0
polyacrylamide
9003-05-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
73-83Subventions
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 093687
Pays : United Kingdom
Informations de copyright
Copyright © 2019 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
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