Coriandrum sativum seeds extract mitigate progression of diabetic nephropathy in experimental rats via AGEs inhibition.
Animals
Binding Sites
Blood Glucose
/ analysis
Coriandrum
/ chemistry
Creatinine
/ blood
Diabetes Mellitus, Experimental
/ chemically induced
Diabetic Nephropathies
/ drug therapy
Gas Chromatography-Mass Spectrometry
Glutathione
/ metabolism
Glycation End Products, Advanced
/ antagonists & inhibitors
Lipid Peroxidation
/ drug effects
Lipids
/ blood
Male
Molecular Docking Simulation
Plant Extracts
/ chemistry
Rats
Rats, Wistar
Seeds
/ chemistry
Superoxide Dismutase
/ metabolism
Terpenes
/ analysis
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2019
2019
Historique:
received:
29
10
2018
accepted:
17
02
2019
entrez:
8
3
2019
pubmed:
8
3
2019
medline:
4
12
2019
Statut:
epublish
Résumé
Inthe present study, we have demonstrated the phytochemical composition of petroleum ether extract of C. sativum (CPE) seeds by using chromatographic, spectroscopic as well spectrometric analysis. CPE was evaluated for its possible role in mitigation of diabetic nephropathy (DN) in Streptozotocin (STZ)-nicotinamide (NAD) induced type 2 diabetes model. Administration of CPE at doses of 100, 200, and 400 mg/kg for 45 days has produced significant attenuation of elevated biochemical parameters including serum glucose, lipid and creatinine levels. CPE has also reserved albuminuria and elevated creatinine clearance in treated diabetic rats. Advanced glycation end products (AGEs) formation in kidneyswas also considerably reduced along with noteworthy increase in level of superoxide dismutase (SOD), glutathione (GSH), and decrease in lipid peroxidation in terms of thiobarbituric acid reactive species (TBARS). Molecular docking studies were also employed to reveal out the possible mechanism. In conclusion, using STZ-NAD model, we have successfully predicted that by assets of bioactive constituents CPE might inhibit the progression of DN. C. sativum may act as potential adjuvant for antidiabetic therapy and needs to be investigated further.
Identifiants
pubmed: 30845182
doi: 10.1371/journal.pone.0213147
pii: PONE-D-18-31150
pmc: PMC6405108
doi:
Substances chimiques
Blood Glucose
0
Glycation End Products, Advanced
0
Lipids
0
Plant Extracts
0
Terpenes
0
Creatinine
AYI8EX34EU
Superoxide Dismutase
EC 1.15.1.1
Glutathione
GAN16C9B8O
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0213147Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
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