Quantitative assessment of airway remodelling and response to allergen in asthma.
asthma
bronchoscopy and interventional techniques
radiology and other imaging
respiratory function test
respiratory structure and function
Journal
Respirology (Carlton, Vic.)
ISSN: 1440-1843
Titre abrégé: Respirology
Pays: Australia
ID NLM: 9616368
Informations de publication
Date de publication:
11 2019
11 2019
Historique:
received:
18
09
2018
revised:
12
02
2019
accepted:
17
02
2019
pubmed:
8
3
2019
medline:
30
5
2020
entrez:
8
3
2019
Statut:
ppublish
Résumé
In vivo evaluation of the microstructural differences between asthmatic and non-asthmatic airways and their functional consequences is relevant to understanding and, potentially, treating asthma. In this study, we use endobronchial optical coherence tomography to investigate how allergic airways with asthma differ from allergic non-asthmatic airways in baseline microstructure and in response to allergen challenge. A total of 45 subjects completed the study, including 20 allergic, mildly asthmatic individuals, 22 non-asthmatic allergic controls and 3 healthy controls. A 3-cm airway segment in the right middle and right upper lobe were imaged in each subject immediately before and 24 h following segmental allergen challenge to the right middle lobe. Relationships between optical airway measurements (epithelial and mucosal thicknesses, mucosal buckling and mucus) and airway obstruction (FEV Significant increases at baseline and in response to allergen were observed for all four of our imaging metrics in the asthmatic airways compared to the non-asthmatic airways. Epithelial thickness and mucosal buckling exhibited a significant relationship to FEV Simultaneous assessments of airway microstructure, buckling and mucus revealed both structural and functional differences between the mildly asthmatic and control groups, with airway buckling seeming to be the most relevant factor. The results of this study demonstrate that a comprehensive, microstructural approach to assessing the airways may be important in future asthma studies as well as in the monitoring and treatment of asthma.
Sections du résumé
BACKGROUND AND OBJECTIVE
In vivo evaluation of the microstructural differences between asthmatic and non-asthmatic airways and their functional consequences is relevant to understanding and, potentially, treating asthma. In this study, we use endobronchial optical coherence tomography to investigate how allergic airways with asthma differ from allergic non-asthmatic airways in baseline microstructure and in response to allergen challenge.
METHODS
A total of 45 subjects completed the study, including 20 allergic, mildly asthmatic individuals, 22 non-asthmatic allergic controls and 3 healthy controls. A 3-cm airway segment in the right middle and right upper lobe were imaged in each subject immediately before and 24 h following segmental allergen challenge to the right middle lobe. Relationships between optical airway measurements (epithelial and mucosal thicknesses, mucosal buckling and mucus) and airway obstruction (FEV
RESULTS
Significant increases at baseline and in response to allergen were observed for all four of our imaging metrics in the asthmatic airways compared to the non-asthmatic airways. Epithelial thickness and mucosal buckling exhibited a significant relationship to FEV
CONCLUSION
Simultaneous assessments of airway microstructure, buckling and mucus revealed both structural and functional differences between the mildly asthmatic and control groups, with airway buckling seeming to be the most relevant factor. The results of this study demonstrate that a comprehensive, microstructural approach to assessing the airways may be important in future asthma studies as well as in the monitoring and treatment of asthma.
Identifiants
pubmed: 30845351
doi: 10.1111/resp.13521
pmc: PMC6732047
mid: NIHMS1033098
doi:
Substances chimiques
Allergens
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1073-1080Subventions
Organisme : NCI NIH HHS
ID : R01 CA167827
Pays : United States
Organisme : NIAID NIH HHS
ID : K08 AI125816
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL133664
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI040618
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI095261
Pays : United States
Commentaires et corrections
Type : CommentIn
Informations de copyright
© 2019 Asian Pacific Society of Respirology.
Références
N Engl J Med. 2006 Jun 15;354(24):2613-6; author reply 2613-6
pubmed: 16775244
N Engl J Med. 2011 May 26;364(21):2006-15
pubmed: 21612469
Thorax. 2002 Mar;57(3):247-53
pubmed: 11867830
Am J Respir Crit Care Med. 2007 Jul 15;176(2):138-45
pubmed: 17463414
Am Rev Respir Dis. 1993 Feb;147(2):405-10
pubmed: 8430966
Physiology (Bethesda). 2005 Feb;20:28-35
pubmed: 15653837
Opt Express. 2003 Apr 7;11(7):782-93
pubmed: 19461791
Sci Transl Med. 2016 Oct 5;8(359):359ra131
pubmed: 27708064
Nat Med. 2006 Dec;12(12):1429-33
pubmed: 17115049
Chest. 2003 Jul;124(1):32-41
pubmed: 12853499
Biomed Opt Express. 2017 Sep 26;8(10):4729-4741
pubmed: 29082098
J Appl Physiol (1985). 2013 Apr;114(7):834-43
pubmed: 23305987
J Immunol. 2007 Aug 1;179(3):1901-12
pubmed: 17641057
J Allergy (Cairo). 2012;2012:316049
pubmed: 22315625
Am J Respir Crit Care Med. 2001 Jun;163(7):1669-75
pubmed: 11401892
Sci Transl Med. 2016 Oct 5;8(359):359ra132
pubmed: 27708065
Science. 1991 Nov 22;254(5035):1178-81
pubmed: 1957169
J Asthma. 1993;30(4):257-62
pubmed: 8331037
Proc Am Thorac Soc. 2009 Aug 15;6(5):439-43
pubmed: 19687216
Lancet. 2008 Sep 20;372(9643):1107-19
pubmed: 18805339
Am J Respir Crit Care Med. 2001 Feb;163(2):517-23
pubmed: 11179133
J Allergy Clin Immunol. 2013 Jun;131(6):1644-52
pubmed: 23632297
J Appl Physiol (1985). 1997 Dec;83(6):1814-21
pubmed: 9390950
Allergy Asthma Immunol Res. 2011 Apr;3(2):111-7
pubmed: 21461250
Am J Respir Crit Care Med. 2000 Oct;162(4 Pt 1):1518-23
pubmed: 11029371
Chest. 2005 Jun;127(6):1999-2006
pubmed: 15947312
Arch Pathol Lab Med. 2012 Dec;136(12):1492-501
pubmed: 23194041
J Allergy Clin Immunol. 2001 Nov;108(5):738-46
pubmed: 11692098
Thorax. 1998 Apr;53(4):248-53
pubmed: 9741365
Curr Opin Allergy Clin Immunol. 2012 Feb;12(1):39-41
pubmed: 22157151