Reactive Species Interactome Alterations in Oocyte Donation Pregnancies in the Absence and Presence of Pre-Eclampsia.
hydrogen sulfide
nitric oxide
oocyte donation
pre-eclampsia
reactive species interactome
thiols
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
06 03 2019
06 03 2019
Historique:
received:
28
01
2019
revised:
20
02
2019
accepted:
26
02
2019
entrez:
9
3
2019
pubmed:
9
3
2019
medline:
2
7
2019
Statut:
epublish
Résumé
In pregnancy, maternal physiology is subject to considerable adaptations, including alterations in cardiovascular and metabolic function as well as development of immunological tolerance towards the fetus. In an oocyte donation pregnancy, the fetus is fully allogeneic towards the mother, since it carries both oocyte donor antigens and paternal antigens. Therefore, oocyte donation pregnancies result in an immunologically challenging pregnancy, which is reflected by a higher-than-normal risk to develop pre-eclampsia. Based on the allogeneic conditions in oocyte donation pregnancies, we hypothesized that this situation may translate into alterations in concentration of stable readouts of constituents of the reactive species interactome (RSI) compared to normal pregnancies, especially serum free thiols, nitric oxide (NO) and hydrogen sulfide (H₂S) related metabolites. Indeed, total free thiol levels and nitrite (NO₂
Identifiants
pubmed: 30845762
pii: ijms20051150
doi: 10.3390/ijms20051150
pmc: PMC6429516
pii:
doi:
Substances chimiques
Sulfhydryl Compounds
0
Nitric Oxide
31C4KY9ESH
Hydrogen Sulfide
YY9FVM7NSN
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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